Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (Artemisia dracunculus)
スポンサーリンク
概要
- 論文の詳細を見る
Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and 3.3 ± 0.2 µM for compound 2, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (Artemisia dracunculus) purchased from a Japanese market.
- 2012-05-23
著者
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Abe Naoki
Dep. Of Nutritional Sci. Fac. Of Applied Bio-science Tokyo Univ. Of Agriculture
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Onose Jun-Ichi
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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SUGAYA Kouichi
Department of Nutritional Science, Faculty of Applied Bio-science, Tokyo University of Agriculture
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Sugaya Kouichi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Onose Jun-ichi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Abe Naoki
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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BRAHMI Zeineb
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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Katho Tatsuya
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Hiroi Asako
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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HATSUMATA Rie
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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MIYAKAWA Nami
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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YAKOU Emi
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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Yakou Emi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Hatsumata Rie
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Miyakawa Nami
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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