Effective Cytochrome P450 (CYP) Inhibitor Isolated from Thyme (Thymus saturoides) Purchased from a Japanese Market
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概要
- 論文の詳細を見る
A highly polymethylated flavone that effectively inhibited cytochrome P450s (CYPs) 1A2 and 3A4 (IC<SUB>50</SUB>=2.41 and 1.71 μM) <I>in vitro</I> was isolated from thyme leaves (<I>Thymus saturoides</I>) purchased from a Japanese market. Its structure was spectroscopically identified as 4′,5-dihydroxy-3′,6,7,8-tetramethoxy flavone (8-methoxycirsilineol, <B>1</B>). This is the first report describing a strong inhibitor of CYP1A2 and 3A4 isolated from <I>Thymus saturoides</I>.
- Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
- 2011-11-23
著者
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Abe Naoki
Dep. Of Nutritional Sci. Fac. Of Applied Bio-science Tokyo Univ. Of Agriculture
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Onose Jun-Ichi
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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SUGAYA Kouichi
Department of Nutritional Science, Faculty of Applied Bio-science, Tokyo University of Agriculture
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Sugaya Kouichi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Onose Jun-ichi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Yasunaga Katsuaki
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Abe Naoki
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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BRAHMI Zeineb
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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NIWA Hitomi
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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YAMASATO Mio
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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SHIGETO Sakurako
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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KUSAKARI Yuna
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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Yamasato Mio
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Niwa Hitomi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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