Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats.

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of acute (24-, 48 or 72-hr) water deprivation on the disposition kinetics of trimethadione (TMO) and its only metabolite, dimethadione (DM0), and on the microsomal hepatic drug-oxidizing enzyme activities were investigated in male rats. The DMO/TMO ratios in the serum at 2 hr after intravenous administration of 100 mg/kg TMO were significantly decreased in 48 and 72-hr water-deprived rats, but in 24-hr water-deprived rats, the DMO/TMO ratios were not changed as compared to controls and food restrictions. In the 48 and 72-hr water-deprived rats, contents of cytochrome p-450 and activities of aminopyrine N-demethylase were significantly decreased. On the other hand, activities of aniline hydroxylase in these rats were significantly increased as compared to controls and food restrictions. These results suggest that the effects of water deprivation on drug metabolism not only depend on the time of water deprivation but also vary with the indicator substrate.

• 公益社団法人 日本薬理学会の論文

著者

• MISAWA Shogo

  Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba

• KUROIWA Yukio

  Department of Biochemical Toxicology, School of Pharmaceutical Science, Showa University

関連論文

• Regional differences in homicide patterns in five areas of Japan
• TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS
• Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats.

スポンサーリンク