A COMPARATIVE STUDY OF GENE EXPRESSION PROFILES IN RAT LIVER AFTER ADMINISTRATION OF ALPHA-HEXACHLOROCYCLOHEXANE AND LINDANE
スポンサーリンク
概要
- 論文の詳細を見る
Alpha-hexachlorocyclohexane (alpha-HCH) is a stereoisomer of gamma-HCH, the active ingredient of lindane (> 99% gamma-HCH). In the present study, cDNA microarray technology was employed to identify changes in gene expression associated with toxicity in livers of male Fischer 344 rats after treatment with alpha-HCH (2, 20 mg/kg/day) and lindane (1, 10 mg/kg/day) by daily oral gavage for up to 28 days. Liver samples were obtained after 1, 3, 7, 14 and 28 days and compared for gene expression profiles. The dose of the alpha-HCH was higher than that of lindane and toxicity was greater, but the numbers of probe sets with differences in expression were fewer for the alpha-HCH-treated group except on Day 3. Only very few probe sets with differences in expression overlapped between alpha-HCH and lindane at each time point and the gene expression profiles were very dissimilar. Important liver-based differences in expression between alpha-HCH and lindane might possibly account for hepato-carcinogenicity of alpha-HCH.
- 2007-08-17
著者
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高橋 智
首都大学東京 大学院理工学研究科機械工学専攻
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Tamano S
Dims Institute Of Medical Science Inc.
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SAITO Koichi
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Shirai T
Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University
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Shirai Tomoyuki
ボゾリサーチセンター御殿場研究所
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SUMIDA Kayo
Sumitomo Chemical Co. Ltd.
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Sugimura T
Cancer Prevention Basic Research Project National Cancer Center Research Institute
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YAKABE Yoshikuni
Chemicals Evaluation and Research Institute
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Shimokawa T
National Cancer Center Res. Inst. Tokyo Jpn
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SHIRAI Tomoyuki
Nagoya City University Medical School
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Shirai Tomoyuki
Graduate School Of Medical Sciences Nagoya City University
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Nakayama Koji
Mitsubishi Chemical Safety Institute Ltd.
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SAITO Koichi
Sumitomo Chemical Co., Ltd.
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OEDA Kenji
Sumitomo Chemical Co., Ltd.
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OTSUKA Masanori
Chemical Evaluation and Research Institute
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MATSUMOTO Hiroshi
Chemical Evaluation and Research Institute
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SEKIJIMA Masaru
Mitsubishi Chemical Safety Institute Ltd.
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KAWANO Yukiko
Mitsubishi Cenmical Safety Institute Ltd.
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Shirai T
大雄会医科学研究所
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Shirai Tomoyuki
Department Of Mathematics Tokyo Institute Of Technology
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Oeda Kenji
Sumitomo Chemical Co. Ltd.
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Tamano Seiko
First Department Of Pathology Nagoya City University Medical School
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Kawano Yukiko
Mitsubishi Chemical Safety Institute Ltd.
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Sugimura T
Carcinogenesis Division National Cancer Center Research Institute
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Shirai Tomoyuki
Pathology Group Yakult Central Inst.
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Shirai Tomoyuki
Nagoya City Univ. Postgraduate School Of Medical Sci. Nagoya
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Yakabe Yoshikuni
Chemical Evaluation And Research Institute
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Sekijima Masaru
Mitsubishi Chemical Medience Co. Ltd.
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Saito Koichi
Sumitomo Chemical Co. Ltd.
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Kitamoto Sachiko
Environmental Health Sci. Lab. Sumitomo Chemical Co. Ltd.
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Tamano Seiko
Daiyu-kai Institute Of Medical Science
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