Determination of Urinary and Serum Pentosidine and Its Application to Elder Patients
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概要
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Pentosidine, a fluorescent cross-linking compound, accumulates in extracellular matrix, espcially in the collagen, and is formed by the nonenzymatic process of advanced Maillard reaction. We developed a method of determination of pentosidine and tried to examine its level in urine and serum of elder patients. The method, which involves the hydrolysis of samples, pretreatment using a CF-11 cellulose column and HPLC quantification, resulted in a high recovery (94.3%) of pentosidine with low coefficient of variation (8-10%) of total analysis. Serum and urinary levels of pentosidine in control subjects gradually increased with age. Elder patients with cerebral infarction showed higher levels of serum and urinary pentosidine as compared with those with senile dementia and other geriatric disorders. These results suggest that serious damage to systemic vascular tissues has already occurred in these patients due to glycation.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
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TAKAHASHI Satoru
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
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SAITO NOBUHIKO
Department of Internal Medicine, Mita Hospital of International University of Health and Welfare
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Nagata M
School Of Pharmacy Tokyo University Of Pharmcy And Life Science
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YOSHIHARA Kazuhiro
School of Pharmacy, Tokyo University of Pharmcy and Life Science
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NAKAMURA Kyoko
School of Pharmacy, Tokyo University of Pharmcy and Life Science
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KANAI Manabu
School of Pharmacy, Tokyo University of Pharmcy and Life Science
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NAGAYAMA Yoshiaki
Department of Internal Medicine, School of Medicine St. Marianna University
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NAGATA Minoru
School of Pharmacy, Tokyo University of Pharmcy and Life Science
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Kanai Manabu
School Of Pharmacy Tokyo University Of Pharmcy And Life Science
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Nagayama Yoshiaki
Department Of Internal Medicine School Of Medicine St. Marianna University
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Saito Nobuhiko
Department Of Applied Physics Waseda University
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Takahashi Satoru
Department Of Anatomy And Embryology Biomolecular And Integrated Medical Sciences Graduate School Of
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Saito Nobuhiko
Department Of Applied Physics School Of Science And Engineering Waseda University
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Saito Nobuhiko
Department Of Internal Medicine School Of Medicine St. Marianna University
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Nakamura Kyoko
School Of Pharmacy Tokyo University Of Pharmcy And Life Science
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Yoshihara Kazuhiro
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yoshihara Kazuhiro
School Of Pharmacy Tokyo University Of Pharmcy And Life Science
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Saito Nobuhiko
Department Of Applied Physics Faculty Of Sciencc And Engineering Waseda University
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Saito Nobuhiko
Department Of Applied Physics And Science And Engineering Research Institute Waseda University
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Yoshihara Kazuhiko
School of Pharmacy, Tokyo University of Pharmcy and Life Science
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