Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Extracellular-superoxide dismutase [EC 1.15.1.1] (EC-SOD) is a secretory glycoprotein with high affinity for heparin. This enzyme locates in blood vessel walls at a high enough level to suppress oxidative stress under normal conditions. EC-SOD is the major SOD isozyme in plasma, anchored to heparan sulfate proteoglycans in the glycocalyx of endothelial cell surfaces. Plasma EC-SOD is heterogeneous in heparin affinity and can be divided into five fractions, I to V, by heparin-HPLC. It has been suggested that EC-SOD form V is the primacy form synthesized in the body and that EC-SOD forms with reduced heparin affinity are the result of proteolytic truncation of the C-terminal end of EC-SOD form V which is responsible for the binding with heparin. Recently, we reported that only plasma EC-SOD form V, with the highest heparin affinity, was incresed by intravenous injection of heparin. The heparin affinity of plasma EC-SOD in patients with coronary atherosclerosis (CA+ patients) was compared in this study. The increase of plasma EC-SOD from V after heparin injection in CA+ patients was significantly less than that in subjects without evidence of stenosis in their major coronary arteries (CA- subjects). On the other hand, in CA+ patients, EC-SOD forms I to III, with low heparin affinity, were significantly increased compared to those in CA- subjects. EC-SOD in plasma apparently forms an equilibrium between the plasma phase and endothelial cell surface, and EC-SOD on the endothelial cell surface contributes to protecting the vessel wall against oxidative stress. The findings suggest that the quantitative and qualitative changes of EC-SOD, i.e., the decrease of bound EC-SOD on the endothelial cell surface, might suppress the defense systems against oxidative stress, which causes in part the development of coronary artery atherosclerosis.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
-
HIRANO Kazuyuki
Department ofPharmaceutics, Glfu Pharmaceutical University
-
Yamazaki Naoya
Department of Dermatology, National Cancer Center
-
Yamazaki N
New Drug Dev. Res. Center Inc. Hokkaido Jpn
-
ADACHI Tetsuo
岐阜薬科大学薬剤学教室
-
Yamazaki Naoya
Department Of Dermatology National Cancer Center
-
Adachi T
Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University
-
ADACHI Tetsuo
Laboratory of clinical Pharmaceutics, Gifu Pharmaceutical University
-
Adachi Tetsuo
Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University
-
TASAKI Hiromi
Department of Internal Medicine, University of Occupational and Environmental Health
-
TOYOKAWA Tsuyoshi
Department of Internal Medicine, University of Occupational and Environmental Health
-
YAMASHITA Kazuhito
Department of Internal Medicine, University of Occupational and Environmental Health
-
Hirano Kazuyuki
Radioisotope Laboratory And Department Of Pharmaceutics Gifu Pharmaceutical University
-
Hirano Kazuyuki
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
-
Tasaki Hiromi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health Japan Sc
-
Yamamoto Kiyoko
The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ
-
Toyokawa Tsuyoshi
Second Department Of Internal Medicine.university Of Occupational And Environmental Health School Of
-
Yamashita Kazuhito
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
-
Adachi Tetsuo
Lab. Of Clinical Pharmaceutics Gifu Pharmaceutical Univ.
-
HIRANO Kazuyuki
Department of Clinical Chemistry School of Health Sciences, Fujita Health University
-
Tasaki Hiromi
Department of Internal Medicine, Emergency and Critical Care Medical Center, Kitakyushu Municipal Yahata Hospital
-
Yamashita Kazuhito
Department of Immunobiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
関連論文
- Gastric Tumorigenicity of 1,2-Dimethylhydrazine on the Background of Gastric Intestinal Metaplasia Induced by X-Irradiation in CD (SD) Rats
- Changes in the Cyclin D1 Gene Copy Number in Melanoma Cell Lines Detected by Double-Target Fluorescence in situ Hybridization
- Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
- Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy
- Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells^1
- Induction of Necrosis by Zinc in Prostate Carcinoma Cells and Identification of Proteins Increased in Association with This Induction.
- ELISA for human tissue-unspecific (liver/bone/kidney) alkaline phosphatase.
- Serum and tissue levels of manganese superoxide dismutase in testicular germ tumors.
- Modulation of Reactive Oxygen Species in Endothelial Cells by Peroxynitrite-Treated Lipoproteins
- Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver
- Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives.
- Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
- Variable Glyceryl Dinitrate Formation as a Function of Glutathione S-Transferase
- Inhibition of Purified Human Sucrase and Isomaltase by Ethanolamine Derivatives
- In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
- HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
- Protective Role of Extracellular Superoxide Dismutase in Hemodialysis Patients.
- Polymorphism of Extracellular Superoxide Dismutase(EC-SOD) Gene : Relation to the Mutation Responsible for High EC-SOD Level in Serum.
- POLYMORPHISM OF EXTRACELLULAR SUPEROXIDE DISMUTASE (EC-SOD) GENE : RELATION TO THE MUTATION RESPONSIBLE FOR HIGH EC-SOD LEVEL IN SERUM
- Effect of Superoxide Dismutase on Glomerular Nephritis.
- Determination of Mitochondrial Aspartate Aminotransferase in Serum.
- Drug-binding Properties of Human α-Foetoprotein.
- INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
- EFFECT OF SUPEROXIDE DISMUTASE ON RATS INDUCED KIDNEY INTOXICATION
- DETERMINATION OF ADRIAMYCIN BY ENZYME IMMUNOASSAY
- SUPEROXIDE DISMUTASE LEVELS FOLLOWING LIVER AND KIDNEY INTOXICATION
- RELATION BETWEEN CARDIOTOXIC EFFECT OF ADRIAMYCIN AND SUPEROXIDE DISMUTASE
- Circulating extracellular superoxide dismutase antagonizes blood pressure elevation in patients with coronary artery disease
- A One-step Enzyme Immunoassay for Human Manganese Superoxide Dismutase with Monoclonal Antibodies.
- Serum Manganese-Superoxide Dismutase Level in Patients with Liver Diseases
- DIFFERENTIAL DETERMINATION OF CATIONIC AND ANIONIC GLUTATHIONE S-TRANSFERASES BY ENZYME IMMUNOASSAY
- Angiotensin Receptor Blocker Improves Coronary Flow Velocity Reserve in Hypertensive Patients : Comparison with Calcium Channel Blocker
- PJ-425 Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Correlated with Cxidative Stress Markers in Stable Coronary Artery Disease(Atherosclerosis, clinical-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-015 Decreased Plasma Extracellular Superoxide Dismutase Level in Patients with Vasospastic Angina(Angina pectoris, basic/clinical-3 (IHD) PE3,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-177 Gene Transfer of Human Extracellular Superoxide Dismutase Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats(Pulmonary circulation-2 (H) OJ30,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- Upregulation of Vascular Extracellular Superoxide Dismutase in Patients With Congestive Heart Failure (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cuff-induced Neointimal Formation is Reduced by Extracellular Superoxide Dismutase(Atherosclerosis, Basic 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Hyperhomocysteinemia is Associated With Human Coronary Atherosclerosis Through the Reduction of the Ratio of Endothelium-Bound to Basal Extracellular Superoxide Dismutase
- Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation.
- Analysis of inquiries about prescriptions at the Pharmacy of Gifu Pharmaceutical University.
- Effects of Homocysteine on the Binding of Extracellular-Superoxide Dismutase to the Endothelial Cell Surface.
- Plasma Extracellular-Superoxide Dismutase in Healthy Newborns and Infants/Children.
- Heparin-Induced Release of Extracellular-Superoxide Dismutase Form (V) to Plasma
- The heparin-binding site of human xanthine oxidase.
- High blood superoxide dismutase (SOD) states in patients with diabetes mellitus. : Dependence on extracellular (EC)-SOD.
- Correlation between Oxidized LDL and Granulocyte Elastase in Patients with Diabetes Mellitus.
- Increase of Urinary Extracellular-Superoxide Dismutase Level Correlated with Cyclic Adenosine Monophosphate.
- Writing Waveguides in Silica-related Glasses with Femtosecond Laser
- Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts.
- Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis.
- Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis
- Substitution of glycine for arginine-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface.
- An arginine-213 to glycine mutation in human extracellularsuperoxide dismutase reduces susceptibility to trypsin-like proteinases.
- An Arginine-213 to Glycine Mutation in Human Extracellular-Superoxide Dismutase Reduces Susceptibility to Trypsin-Like Proteinases
- The Effect of Ethanolamine on Acute Carbon Tetrachloride Intoxication
- Buformin Suppresses the Expression of Glyceraldehyde 3-Phosphate Dehydrogenase(Biopharmacy)
- Regulators for Blood Glucose Level Affect Gene Expression of Aquaporin 3(Biopharmacy)
- Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines
- Competitive Enzyme Immunoassay for Anti-ulcer Agent, (-)-cis-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one Hydrochloride (BTM-1086).
- Studies on Superoxide Dismutase in Human Skin (4). : Contents of Superoxide Dismutase and Lipid Peroxide in Keloid, Hypertrophic Scar and Scar.
- Studies on Superoxide Dismutase in Human Skin (3). : Contents of Superoxide Dismutase and Lipid Peroxide in Skin of Patients with Atopic Dermatitis.
- AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
- Structural Features and Hypoglycemic Activity of a Polysaccharide (CS-F10) from the Cultured Mycelium of Cordyceps sinensis
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor
- Growth Suppressing Factor for Endothelial Cells Exhibits Tumor Regressing Activity
- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells
- Dacarbazine, Nimustine Hydrochloride, Cisplatin and Tamoxifen Combination Chemotherapy for Advanced Malignant Melanoma
- Statistical profiles of malignant melanoma and other skin cancers in Japan : 2007 update
- Extracellular-superoxide dismutase in cerebrospinal fluid from infants/children.
- Molecular analysis of extracellular-superoxide dismutase gene associated with high level in serum.
- MOLECULAR ANALYSIS OF EXTRACELLULAR-SUPEROXIDE DISMUTASE GENE ASSOCIATED WITH HIGH LEVEL IN SERUM
- Purification and Characterization of Pranlukast Hydrolase from Rat Liver Microsomes : The Hydrolase is Identical to Carboxylesterase pI 6.2
- Heparin-affinity of human extracellular-superoxide dismutase in the brain.
- Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface.
- Heparin-Affinity of Human Extracellular-Superoxide Dismutase in the Brain
- The alkaline phosphatase in human plexus chorioideus.
- Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface.
- The Heparin Binding Site of Human Extracellular-Superoxide Dismutase.
- The Site of Nonenzymic Glycation of Human Extracellular-Superoxide Dismutase in vitro.
- Non-enzymic glycation of human extracellular superoxide dismutase.
- Internalization of human extracellular-superoxide dismutase by bovine aortic endothelial cells.
- The nature of heterogeneous components of extracellular-superoxide dismutase purified from human umbilical cords.
- Quantitative Analysis of Extracellular-Superoxide Dismutase in Serum and Urine by ELISA with Monoclonal Antibody.
- An Enzyme Immunoassay for Cuprozinc Superoxide Dismutase Using Monoclonal Antibodies. : Application for Pharmacokinetic Study.
- Effect of fundal pressure on maternal to fetal microtransfusion at the time of cesarean delivery
- Extracellular superoxide dismutase level in chronic hemodialysis patients.
- DECOMPOSITION OF HYDROPEROXIDES DERIVED FROM MICROSOMES OR LIPOPROTEIN BY GLUTATHIONE PEROXIDASE AND GLUTATHIONE S-TRANSFERASE
- Heparin-induced release of extracellular-superoxide dismutase form(V) to plasma.
- Quantitative and qualitative changes of extracellular-superoxide dismutase in patients with various diseases.
- Pedigree of serum extracellular-superoxide dismutase level.
- Effect of Hypoxia Mimetic Cobalt Chloride on the Expression of Extracellular-Superoxide Dismutase in Retinal Pericytes
- Clinicopathological significance of sentinel node biopsy in Japanese patients with cutaneous malignant melanoma
- Chemical Nature of Intestinal-Type Alkaline Phosphatase in Human Kidney.
- Pathologic Background of Abnormal Serum Amyloid A and Interleukin-6 Levels Revealed by a Piecewise Linear Regression Model in the Population of Diabetic Patients
- A Case of Eruptive Vellus Hair Cysts.
- Propolis Suppresses CdCl2-Induced Cytotoxicity of COS7 Cells through the Prevention of Intracellular Reactive Oxygen Species Accumulation
- Extracellular-Superoxide Dismutase Expression in COS7 Cells Exposed to Cadmium Chloride
- Effects of Interactions with Cyclic Solvent Molecules on Optical Dephasing of CdSe/ZnS Colloidal Quantum Dots Detected by Femtosecond Four-Wave Mixing Spectroscopy
- Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma : A multi-institutional study of 450 patients in Japan
- Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma