DECOMPOSITION OF HYDROPEROXIDES DERIVED FROM MICROSOMES OR LIPOPROTEIN BY GLUTATHIONE PEROXIDASE AND GLUTATHIONE S-TRANSFERASE
スポンサーリンク
概要
- 論文の詳細を見る
Protective effects of glutathione peroxidase, glutathione S-transferase purified from human liver and superoxide dismutase against lipid peroxidation were investigated. In the presence of glutathione, lipid hydroperoxides found in microsomal membrane were decomposed by glutathione peroxidase and cationic glutathione S-transferase, but anionic glutathione S-transferase had no effect on them. Superoxide dismutase exhibited antioxidation effect by preventing accumulation of lipid hydroperoxides. Serum lipid hydroperoxides existing in low density lipoprotein fraction were also decomposed by glutathione peroxidase and cationic glutathione S-transferase. These findings suggest that the hydroperoxide level, which has high toxicity, could be controlled by these glutathione-dependent glutathione peroxidase and cationic glutathione S-transferase.
- 公益社団法人日本薬学会の論文
著者
-
HIRANO Kazuyuki
Gifu Pharmaceutical University
-
Adachi T
Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University
-
Adachi Tetsuo
Gifu Pharmaceutical University
-
SUGIURA MAMORU
Gifu College of Pharmacy
-
MIWA TOSHINOBU
Gifu College of Pharmacy
-
Adachi Tetsuo
Lab. Of Clinical Pharmaceutics Gifu Pharmaceutical Univ.
関連論文
- Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression
- Apparent Increase of Insulin Peak Area in HPLC Analysis of a Preparation Consisting of a Mixture of Insulin and Total Parenteral Nutrition
- Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
- Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy
- P-254 SYNTHESIS AND ANTI-PROLIFERATIVE ACTIVITY OF N-(ω-DIPHENYLALKYL)-4-PHENYLPIPERIDINES DESIGNED FROM OPIOID DERIVATIVES
- Induction of Necrosis by Zinc in Prostate Carcinoma Cells and Identification of Proteins Increased in Association with This Induction.
- ELISA for human tissue-unspecific (liver/bone/kidney) alkaline phosphatase.
- Serum and tissue levels of manganese superoxide dismutase in testicular germ tumors.
- Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver.
- Hydrolytic Profile for Ester- or Amide-linkage by Carboxylesterases pI 5.3 and 4.5 from Human Liver
- Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
- Variable Glyceryl Dinitrate Formation as a Function of Glutathione S-Transferase
- Inhibition of Purified Human Sucrase and Isomaltase by Ethanolamine Derivatives
- In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
- HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
- Protective Role of Extracellular Superoxide Dismutase in Hemodialysis Patients.
- Polymorphism of Extracellular Superoxide Dismutase(EC-SOD) Gene : Relation to the Mutation Responsible for High EC-SOD Level in Serum.
- POLYMORPHISM OF EXTRACELLULAR SUPEROXIDE DISMUTASE (EC-SOD) GENE : RELATION TO THE MUTATION RESPONSIBLE FOR HIGH EC-SOD LEVEL IN SERUM
- Effect of Superoxide Dismutase on Glomerular Nephritis.
- Determination of Mitochondrial Aspartate Aminotransferase in Serum.
- Drug-binding Properties of Human α-Foetoprotein.
- INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
- EFFECT OF SUPEROXIDE DISMUTASE ON RATS INDUCED KIDNEY INTOXICATION
- DETERMINATION OF ADRIAMYCIN BY ENZYME IMMUNOASSAY
- SUPEROXIDE DISMUTASE LEVELS FOLLOWING LIVER AND KIDNEY INTOXICATION
- RELATION BETWEEN CARDIOTOXIC EFFECT OF ADRIAMYCIN AND SUPEROXIDE ANION RADICAL
- ENZYME IMMUNOASSAY FOR MANGANESE-SUPEROXIDE DISMUTASE IN SERUM AND URINE
- ENZYME IMMUNOASSAY FOR CUPROZINC-SUPEROXIDE DISMUTASE IN SERUM AND URINE
- MICROASSAYS OF SERUM BILE ACIDS AND ANDROSTERONE BY ENZYME CYCLING METHOD
- PURIFICATION OF SUPEROXIDE DISMUTASES FROM HUMAN PLACENTA USING IMMUNOADSORBENT COLUMNS
- PURIFICATION AND PROPERTIES OF TWO SUPEROXIDE DISMUTASES FROM HUMAN PLACENTA
- NEW METHOD FOR THE ASSAY OF PURINE METABOLIC ENZYMES
- A One-step Enzyme Immunoassay for Human Manganese Superoxide Dismutase with Monoclonal Antibodies.
- Serum Manganese-Superoxide Dismutase Level in Patients with Liver Diseases
- DIFFERENTIAL DETERMINATION OF CATIONIC AND ANIONIC GLUTATHIONE S-TRANSFERASES BY ENZYME IMMUNOASSAY
- Angiotensin Receptor Blocker Improves Coronary Flow Velocity Reserve in Hypertensive Patients : Comparison with Calcium Channel Blocker
- PJ-425 Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Correlated with Cxidative Stress Markers in Stable Coronary Artery Disease(Atherosclerosis, clinical-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-015 Decreased Plasma Extracellular Superoxide Dismutase Level in Patients with Vasospastic Angina(Angina pectoris, basic/clinical-3 (IHD) PE3,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-177 Gene Transfer of Human Extracellular Superoxide Dismutase Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats(Pulmonary circulation-2 (H) OJ30,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- Upregulation of Vascular Extracellular Superoxide Dismutase in Patients With Congestive Heart Failure (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cuff-induced Neointimal Formation is Reduced by Extracellular Superoxide Dismutase(Atherosclerosis, Basic 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Hyperhomocysteinemia is Associated With Human Coronary Atherosclerosis Through the Reduction of the Ratio of Endothelium-Bound to Basal Extracellular Superoxide Dismutase
- Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation.
- Analysis of inquiries about prescriptions at the Pharmacy of Gifu Pharmaceutical University.
- Effects of Homocysteine on the Binding of Extracellular-Superoxide Dismutase to the Endothelial Cell Surface.
- Plasma Extracellular-Superoxide Dismutase in Healthy Newborns and Infants/Children.
- Heparin-Induced Release of Extracellular-Superoxide Dismutase Form (V) to Plasma
- Increase of Urinary Extracellular-Superoxide Dismutase Level Correlated with Cyclic Adenosine Monophosphate.
- Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts.
- Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis.
- Changes in the Heparin Affinity of Extracellular-Superoxide Dismutase in Patients with Coronary Artery Atherosclerosis
- An Arginine-213 to Glycine Mutation in Human Extracellular-Superoxide Dismutase Reduces Susceptibility to Trypsin-Like Proteinases
- Pharmacokinetics of Granisetron in Adults and Children with Malignant Diseases
- A Rapid Assay of Granisetron in Biological Fluids from Cancer Patients
- Determination of Human Alkaline Phosphatase Isozymes by Use of Monoclonal Antibodies and their Clinical Application
- Competitive Enzyme Immunoassay for Anti-ulcer Agent, (-)-cis-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one Hydrochloride (BTM-1086).
- Studies on Superoxide Dismutase in Human Skin (4). : Contents of Superoxide Dismutase and Lipid Peroxide in Keloid, Hypertrophic Scar and Scar.
- Studies on Superoxide Dismutase in Human Skin (3). : Contents of Superoxide Dismutase and Lipid Peroxide in Skin of Patients with Atopic Dermatitis.
- Tomato Paste Fraction Inhibiting the Formation of Advanced Glycation End-products
- Antidiabetic Effect of an Acidic Polysaccharide (TAP) from Tremella aurantia and Its Degradation Product (TAP-H).
- Antidiabetic Effect of an Acidic Polysaccharide(TAP)from Tremella aurantia and Its Degradation Product(TAP-H)
- Structural Features of an Anti-Diabetic Polysaccharide(TAP) from Tremella aurantia.
- Structural Features of an Anti-Diabetic Polysaccharide (TAP) from Tremella aurantia
- Structural Features and Hypoglycemic Activity of a Polysaccharide(CS-F10) from the Cultured Mycelium of Cordyceps sinensis.
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor.
- Growth Suppressing Factor for Endothelial Cells Exhibits Tumor Regressing Activity.
- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells.
- Structural Features and Hypoglycemic Activity of a Polysaccharide (CS-F10) from the Cultured Mycelium of Cordyceps sinensis
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor
- Growth Suppressing Factor for Endothelial Cells Exhibits Tumor Regressing Activity
- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells
- Correlations of Heparin-Releasable Enzymes on the Endothelium Associated with Dyslipidemia
- Hypercholesterolemia mediated by apoliporotein E affects extracellular suproxide dismutase on the endothelium
- Extracellular-superoxide dismutase in cerebrospinal fluid from infants/children.
- Molecular analysis of extracellular-superoxide dismutase gene associated with high level in serum.
- MOLECULAR ANALYSIS OF EXTRACELLULAR-SUPEROXIDE DISMUTASE GENE ASSOCIATED WITH HIGH LEVEL IN SERUM
- Purification and Characterization of Pranlukast Hydrolase from Rat Liver Microsomes : The Hydrolase is Identical to Carboxylesterase pI 6.2
- Heparin-affinity of human extracellular-superoxide dismutase in the brain.
- Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface.
- Heparin-Affinity of Human Extracellular-Superoxide Dismutase in the Brain
- The alkaline phosphatase in human plexus chorioideus.
- Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface.
- The Heparin Binding Site of Human Extracellular-Superoxide Dismutase.
- The Site of Nonenzymic Glycation of Human Extracellular-Superoxide Dismutase in vitro.
- Non-enzymic glycation of human extracellular superoxide dismutase.
- Chemical Modification of β-Galactosidase from Macrophomina phaseoli with N-Bromosuccinimide
- Internalization of human extracellular-superoxide dismutase by bovine aortic endothelial cells.
- The nature of heterogeneous components of extracellular-superoxide dismutase purified from human umbilical cords.
- Quantitative Analysis of Extracellular-Superoxide Dismutase in Serum and Urine by ELISA with Monoclonal Antibody.
- An Enzyme Immunoassay for Cuprozinc Superoxide Dismutase Using Monoclonal Antibodies. : Application for Pharmacokinetic Study.
- Extracellular superoxide dismutase level in chronic hemodialysis patients.
- STUDIES ON MONOCOMPONENT INSULIN. V. PHARMACOKINETICS OF SOLUBLE INSULIN PREPARATIONS USING IN SITU ANIMAL MODEL
- DETERMINATION OF PURITY AND IDENTIFICATION OF ANIMAL SOURCES OF INSULIN IN VARIOUS INSULIN PREPARATIONS
- DECOMPOSITION OF HYDROPEROXIDES DERIVED FROM MICROSOMES OR LIPOPROTEIN BY GLUTATHIONE PEROXIDASE AND GLUTATHIONE S-TRANSFERASE
- Heparin-induced release of extracellular-superoxide dismutase form(V) to plasma.
- Quantitative and qualitative changes of extracellular-superoxide dismutase in patients with various diseases.
- Pedigree of serum extracellular-superoxide dismutase level.
- Immobilization and Properties of β-Galactosidases from Macrophomina phaseoli and Sclerotium tuliparum
- Chemical Nature of Intestinal-Type Alkaline Phosphatase in Human Kidney.
- A Case of Eruptive Vellus Hair Cysts.