Tomato Paste Fraction Inhibiting the Formation of Advanced Glycation End-products
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概要
- 論文の詳細を見る
A water-soluble and low-molecular-weight fraction (SB) was obtained from tomato paste. The effects of SB on the formation of advanced glycation end-products (AGE) in protein glycation were studied by the methods of specific fluorescence, ELISA and a Western blot analysis, using the anti-AGE antibody after incubating protein with sugar. The results suggest that SB had strong inhibitory activity, in comparison with aminoguanidine as a positive control, and that the inhibitory mechanism of SB differed from that of aminoguanidine to involve trapping of reactive dicarbonyl intermediates in the early stage of glycation. SB contained an antioxidant, rutin, which showed potent inhibitory activity. The results also suggest that rutin chiefly contributed to inhibiting the formation of AGE, and that other compounds in SB may also have been related to the activity.
- 社団法人 日本農芸化学会の論文
- 2004-01-23
著者
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HIRANO Kazuyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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HIRANO Kazuyuki
Gifu Pharmaceutical University
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.,
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USUI Shigeyuki
Gifu Pharmaceutical University
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USUI Shigeyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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Hirano K
Lab. Of Pharmaceutics Gifu Pharmaceutical Univ.
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Hirano K
Gifu Pharmaceutical University
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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AIZAWA Koichi
Research Institute, Kagome Co., Ltd.
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Kiho T
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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Shigeyuki Usui
Gifu Pharmaceutical University
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Usui Shigeyuki
Laboratory Of Pharmaceutics Gifu Pharmaceutical University
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Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
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Kiho T
Gifu Pharmaceutical Univ. Gifu Jpn
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Aizawa Koichi
Research Institute Kagome Co. Ltd.
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Inakuma T
Kagome Co. Ltd.
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Inakuma Takahiro
Res. Inst. Kagome Co. Ltd.
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Inakuma Takahiro
Research Institute Kagome Co. Ltd
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Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Kobayashi Takashi
Gifu Prefectural Institute Of Health And Environmental Sciences
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Inakuma Takahiro
Research Institute, Kagome Company Ltd.
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Horie Kazutoshi
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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