Antidiabetic Effect of an Acidic Polysaccharide(TAP)from Tremella aurantia and Its Degradation Product(TAP-H)
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概要
- 論文の詳細を見る
Continuous oral administration of the acidic polysaccharide(TAP)solution(0.5g/l)and the TAP-H(degradation products of TAP)solution(1.5g/l)instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model(KK-A^y)mice. TAP and TAP-H significantly lowered levels of insulin, total-cholesterol and triglyceride in the blood of the mice. In excretion to feces, TAP an TAP-H significantly increased the total bile acid, while the cholesterol content of both groups was less than that of the control. Furthermore, TAP and TAP-H significantly decreased the plasma lipoperoxide level. The study shows that TAP and TAP-H have an antidiabetic effect on diabetes model mice.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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HIRANO Kazuyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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HIRANO Kazuyuki
Gifu Pharmaceutical University
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.,
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USUI Shigeyuki
Gifu Pharmaceutical University
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USUI Shigeyuki
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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Hirano K
Lab. Of Pharmaceutics Gifu Pharmaceutical Univ.
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Hirano K
Gifu Pharmaceutical University
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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AIZAWA Koichi
Research Institute, Kagome Co., Ltd.
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KOCHI Mari
Gifu Pharmaceutical University
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Kiho T
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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Shigeyuki Usui
Gifu Pharmaceutical University
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Usui Shigeyuki
Laboratory Of Pharmaceutics Gifu Pharmaceutical University
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Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
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Kiho T
Gifu Pharmaceutical Univ. Gifu Jpn
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Aizawa Koichi
Research Institute Kagome Co. Ltd.
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Inakuma T
Kagome Co. Ltd.
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Inakuma Takahiro
Res. Inst. Kagome Co. Ltd.
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Inakuma Takahiro
Research Institute Kagome Co. Ltd
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Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Inakuma Takahiro
Research Institute, Kagome Company Ltd.
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Horie Kazutoshi
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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