Structural Features and Hypoglycemic Activity of a Polysaccharide (CS-F10) from the Cultured Mycelium of Cordyceps sinensis
スポンサーリンク
概要
- 論文の詳細を見る
A polysaccharide (CS-F10) purified from a hot water extract of the cultured mycelium of Cordyceps sinensis was composed of galactose, glucose and mannose in a molar ratio of 43 : 33 : 24; its molecular weight was estimated to be about 15000. The results of chemical and spectroscopic investigations suggest that CS-F10 has a comb-type structure, and has α-D-glucopyranosyl residues on the terminal of the side-chains and characteristic sugar residues of C. sinensis i.e., 1,5-linked β-D-galactofuranosyl residues. CS-F10 significantly lowered the plasma glucose level in normal, streptozotocin (STZ)-induced diabetic and epinephrine-induced hyperglycemic mice after intraperitoneal administration (50 mg/kg). Administration of CS-F10 to STZ-induced diabetic mice significantly increased the activity of hepatic glucokinase. A significant reduction in the hepatic glucose output was observed following the infusion of CS-F10 using the perfused rat liver. CS-F10 also significantly decreased protein content of facilitative glucose transporter isoform 2 (GLUT2) from rat liver following i.p. administration. These effects presumably contribute to the hypoglycemic activity.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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HIRANO Kazuyuki
Gifu Pharmaceutical University
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HIRANO Kazuyuki
Department ofPharmaceutics, Glfu Pharmaceutical University
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Hirano K
Gifu Pharmaceutical University
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USUI Shigeyuki
Department of Pharmaceutics, Gifu Pharmaceutical University
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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KIHO Tadashi
Department of Pharmaceutics, Gifu Pharmaceutical University
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OOKUBO Kako
Department of Pharmaceutics, Gifu Pharmaceutical University
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UKAI Shigeo
Department of Pharmaceutics, Gifu Pharmaceutical University
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Kiho T
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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Usui Shigeyuki
Laboratory Of Pharmaceutics Gifu Pharmaceutical University
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Hirano Kazuyuki
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
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Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
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Kiho T
Gifu Pharmaceutical Univ. Gifu Jpn
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Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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HIRANO Kazuyuki
Department of Clinical Chemistry School of Health Sciences, Fujita Health University
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