Apparent Increase of Insulin Peak Area in HPLC Analysis of a Preparation Consisting of a Mixture of Insulin and Total Parenteral Nutrition
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概要
- 論文の詳細を見る
The peak area of insulin in a mixture of K.C.L.^[○!R]injection and hyperalimentation fluid was found to increase in a time dependent manner up to 24h in measurement by a high-performance liquid chromatograph. The increase of peak area corresponding to the insulin was detected at wavelengths of both 210 and 280nm. This increase was only observed in the presence of the sugars, tryptophan, riboflavin, and insulin, and ascorbate was shown to counteract the increase. These results suggest the possibility that insulin forms a mixture caused by the oxidation reaction in a hyperalimentation fluid.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
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HIRANO Kazuyuki
Gifu Pharmaceutical University
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Yamazaki Futoshi
Ogaki Municipal Hospital Department Of Pharmacy
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ICHIKAWA Etsuko
Ogaki Municipal Hospital, Department of Pharmacy
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KIMURA Michio
Ogaki Municipal Hospital, Department of Pharmacy
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MORI Hiromi
Ogaki Municipal Hospital, Department of Pharmacy
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Mori Hiromi
Ogaki Municipal Hospital Department Of Pharmacy
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Hirano Kazuyuki
Gifu Pharmaceutical University Laboratory Of Pharmaceutics
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Ichikawa Etsuko
Ogaki Municipal Hospital Department Of Pharmacy
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Kimura Michio
Ogaki Municipal Hospital Department Of Pharmacy
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