DETERMINATION OF ADRIAMYCIN BY ENZYME IMMUNOASSAY
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概要
- 論文の詳細を見る
A solid phase immunoassay for the determination of adriamycin has been developed. Specific antibody against adriamycin was raised in rabbits after coupling adriamycin to bovine serum albumin. β-D-Galactosidase labelled adriamycin was prepared by m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) as a coupling reagent. This assay system followed the double antibody solid phase method for the B/F separation of antibodybound and free adriamycin. By this method, from 0.5 to 100 ng of adriamycin could be detected. Using this assay system, drug levels were determined in serum of mice, following administration of adriamycin in a single dose of 15 mg/kg i.p., the peak appearing at 20 min after administration. The change of serum levels was found to be biphasic, and the half-life of β-phase was about 5 h.
- 社団法人日本薬学会の論文
著者
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HIRANO Kazuyuki
Gifu Pharmaceutical University
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Adachi T
Laboratory Of Clinical Pharmaceutics Gifu Pharmaceutical University
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Adachi Tetsuo
Gifu Pharmaceutical University
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ITO YOSHIMASA
Gifu Pharmaceutical University
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NAGAE TADAO
Gifu College of Pharmacy
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SUGIURA MAMORU
Gifu College of Pharmacy
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Hirano Kazuyuki
Radioisotope Laboratory And Department Of Pharmaceutics Gifu Pharmaceutical University
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Adachi Tetsuo
Lab. Of Clinical Pharmaceutics Gifu Pharmaceutical Univ.
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