EFFECT OF 3-DEOXYGLUCOSONE ON THE ACTIVITIES OF ENZYMES RESPONSIBLE FOR GLUCOSE METABOLISM IN MOUSE LIVER
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概要
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Crude extracts containing the enzymes obtained from mouse liver were incubated with 3-deoxyglucosone (3-DG), and then subjected to assay of the activities of enzymes responsible for glucose metabolism. Hexokinase and glucose-6-phosphate dehydrogenase activities were decreased by 3-DG and hexokinase activity was strongly inhibited time and concentration dependently, while glucokinase, glucose-6-phosphatase, and phosphofructokinase activities were scarcely affected. These results suggest that 3-DG inhibits the intake of glucose in the liver and a connection with development of diabetes.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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Asahi Takashi
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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USUI Shigeyuki
Department of Pharmaceutics, Gifu Pharmaceutical University
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KIHO Tadashi
Gifu Prefectural Institute of Health and Environmental Sciences
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KIHO Tadashi
Department of Pharmaceutics, Gifu Pharmaceutical University
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UKAI Shigeo
Department of Pharmaceutics, Gifu Pharmaceutical University
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Kiho T
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kiho Tadashi
Gifu Pharmaceutical University
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Ukai S
Gifu Pharmaceutical Univ. Gifu Jpn
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Kiho T
Gifu Pharmaceutical Univ. Gifu Jpn
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Matsunaga Toshiyuki
Department Of Biochemistry Research Center For Genomic Medicine Saitama Medical School
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