Hashimoto Michizane | Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

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著作論文

The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353 : II. Biological Profiles
Naphthalecin, a Novel Antibiotic Produced by the Anaerobic Bacterium, Sporotalea colonica sp. nov.
FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : II. Biological Profiles
FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : I. Taxonomy of the Producing Organism, Fermentation, Islation and Physico-chemical Properties
FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : II. Biological Activities
FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties
The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No.19353 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) II. Biological Activities in Animal Models
FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 III. In Vivo Activities
FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) I. Taxonomy, Fermentation, Isolation and Biological Activities
FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 II. In Vitro Property and Mode of Action
FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : II. In Vitro and In Vivo Activities
FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : I. Taxonomy, Fermentation, and Biological Properties
FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : II. Biological Properties and Model of Action
FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase III. Structure Determination
A New Antimitotic Substance, FR182877 : II. The Mechanism of Action
Site-specific Structural Transformation of the Novel Antifungal Cyclic Depsipeptide FR901469 : Synthesis and Biological Activity of FR203904
FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : II. In Vitro and In Vivo Antifungal Activity
FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243 : III. Structure Determination
FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
FR198248, a New Anti-influenza Agent isolated from Aspergillus terreus No.13830 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : II. Isolation and Structure Elucidation
Oxidative Activities of Heterologously Expressed CYP107B1 and CYP105D1 in Whole-Cell Biotransformation Using Streptomyces lividans TK24(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : II. Biological Activities
The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
The Novel Gluconeogenesis Inhibitors FR225659 and FR225656 from Helicomyces sp. No. 19353 : III. Structure Determination
FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 I. Taxonomy, Ferimentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523
FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : II. Biological Properties
FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation
FR225659-binding Proteins : Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads
A Comparative Study of Malaysian and Japanese Actinomycetes Using a Simple Identification Method Based on Partial 16S rDNA Sequence
A New Antimitotic Substance, FR182877 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens I. Taxonomy, Production, Purification and Biological Properties
WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production Purification and Structure Elucidation
WF14861, a New Cathepsins B and L Inhibitor Produced by Collectotrichum sp. II. Biological Properties
Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907(METHOD)
Cloning and expression of the FR901379 acylase gene from Streptomyces sd. no. 6907
Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo
Discovery of anti-varicella zoster virus activity of polyether antibiotic CP-44161
Screening and characterization of microorganisms with FR901379 acylase activity
AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase
Cloning and heterologous expression of P450Um-1, a novel bacterial P450 gene, for hydroxylation of immunosuppressive agent AS1387392
Bioconversion of AS1387392 : bioconversion studies involving Amycolatopsis azurea JCM 3275
Bioconversion of AS1387392 : screening and characterization of actinomycetes that convert AS1387392 to AS1429716

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