甘草のフェノール性成分(第4報)甘草のフェノール性成分と基原植物の関係, 並びに各種甘草エキスのXanthine Oxidase及びMonoamine Oxidaseに対する阻害効果
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概要
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The roots and/or rhizomes of Glychyrrhiza uralensis, G. glabra and G. inflata, and commercial licorice specimens from various regions or countries were analyzed by high-performance liquid chromatography (HPLC), and classified into three types based on their phenolic constituents. i) Type A : The roots and rhizomes of G. uralensis, commercial licorice specimens from northwestern region of China (Seihoku-kanzo) and from northeastern region of China (Tohoku-kanzo) in Japanese markets, and also several licorice specimens from Chinese markets. They contain licopyranocoumarin (6), glycycoumarin (7) and/or licocoumarone (8), which were not found in G. glabra and G. inflata. ii) Type B : The root and rhizome of G. glabra, and the licorice specimens imported from the Soviet Union and Afghanistan. They contain glabridin (9) and glabrene (10), which were not found in the samples of the other two Glycyrrhiza species. A root sample of Glycyrrhiza species from Turkey also contains 9 and 10. iii) Type C : The root sample of G. inflata. They contain licochalcones A (11) and B (12), which were not found in the samples of the other two Glycyrrhiza species. Commercial licorice specimens obtained in Japan, which were imported from Sinkiang of China (Shinkyo-kanzo), and some licorice specimens obtained from Chinese markets, have also been found to contain 11 and 12. The phenolics 6-12,characteristic constituents of types A, B or C, were not found in a specimen of cortex-free licorice from a Japanese market (kawasari-kanzo). Extracts of some licorice specimens of types A and B, and all of the licorice specimens of type C inhibited 40-56% of the xanthine oxidase activity at the concentration of 30μg/ml. Extracts of some licorice specimens of types A and B also showed inhibitory effects on monoamine oxidase (44-64% inhibition, at the concentration of 30μg/ml), which were slightly weaker than that of harmane hydrochloride.
- 公益社団法人日本薬学会の論文
- 1991-06-25
著者
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波多野 力
岡山大学薬学部
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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野呂 忠敬
静岡県立大学
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奥村 智子
Faculty Of Pharmaceutical Sciences Okayama University
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奥田 拓男
Takeda Chemical Ind. Ltd. Osaka Jpn
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野呂 忠敬
静岡県立大学 生活健康科学
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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福田 寿之
岡山大学薬学部
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劉 延澤
河南中医学院
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奥田 拓男
静岡県立大学薬学部
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野呂 忠敬
静岡県立大学薬学部
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