Chlorogenic Acid and Its Metabolite m-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells
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概要
- 論文の詳細を見る
We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.
- 社団法人 日本農芸化学会の論文
著者
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HATANO Tsutomu
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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SUN Xiu-Lan
Department of Pharmacognosy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
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ITO Hideyuki
Department of Pharmacognosy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
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Watanabe Makiko
Department of Environmental Science and Technology, Interdisciplinary Graduate School of Science and
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OKAMOTO Motoi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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