Antibodies to Borna Disease Virus in Infected Adult Rats: An Early Appearance of Anti-p10 Antibody and Recognition of Novel Virus-Specific Proteins in Infected Animal Brain Cells.
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概要
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The time course for appearance of antibodies to Borna disease virus (BDV) major antigens, p40, p24, p18 and p10 were investigated in BDV-inoculated adult rats by Western blotting. Anti-p10 antibodies were detected in sera as early as anti-p40 and -p24 antibodies at four or five weeks after inoculation. Furthermore, in addition to these major antigens of BDV, the rat serum could detect additional 80-, 58-, 43-, 20-, and 16-kDa proteins in BDV-infected cultured cells and/or animal brain cells by Western blot analysis. Of these proteins, the 20- and 16-kDa proteins were shown to be related to p24 protein by their reactivity with anti-p24 monoclonal antibody. Interestingly, the 58- and 24-kDa were found only in BDV-infected animal brain cells but not in cultured cells. The results in this study could provide a useful information on the mechanism for the viral replication and pathogenesis.
- 公益社団法人 日本獣医学会の論文
著者
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Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Watanabe Makiko
Department of Environmental Science and Technology, Interdisciplinary Graduate School of Science and
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Tomonaga Keizo
Department Of Veterinary Microbiology The University Of Tokyo
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Ikuta Kazuyoshi
Department Of Biophysical Chemistry Faculity Of Pharmaceutical Sciences Hokkaido University
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