Studies on the Metabolism of Gomisin A (TJN-101). II. : Structure Determination of Biliary and Urinary Metabolites in Rat
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概要
- 論文の詳細を見る
After oral administration of gomisin A (1) to rats, the bile and urine were collected and treated with β-glucuronidase and arylsulfatase. Seven metabolites, met B (2), met A-III (3), met E (4), met D (5), met F (6), met G (7), and met H (8) were isolated from the bile treated with the enzymes. Eight metabolites 2-8,and met A-II (9) were isolated from the urine treated with the enzymes. A major metabolite 2,and two minor metabolites 3 and 9 were identified as met B, met A-III, and met A-II, respectively, which are oxidative products of 1 formed by rat liver S9 mix. The structures of five new metabolites 4-7,and 8 were determined on the basis of chamical and spectral studies.
- 社団法人日本薬学会の論文
- 1990-01-25
著者
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細谷 英吉
ツムラ薬理研究所
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三橋 博
Research Institute for Biology & Chemistry, Tsumura Co., Ltd.,
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三橋 博
津村研究所
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松崎 豊
株式会社 ツムラ ツムラ中央研究所
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池谷 幸信
武蔵野大学薬学部薬学研究所
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Tsumura Institute For Biology And Chemistry
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三橋 博
(株)ツムラ中央研究所
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松崎 豊
株式会社ツムラ ツムラ中央研究所 安全性・代謝研究部
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池谷 幸信
津村研究所
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池谷 幸信
(株)ツムラ中央研究所
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池谷 幸信
Research Institute For Biology & Chemistry Tsumura & Co.
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細谷 英吉
Research Institute For Pharmacology:tsumura & Co.
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松崎 珠絵
株式会社ツムラ薬理研究所
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池谷 幸信
生物・化学研究所
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佐々木 博美
株式会社ツムラ薬理研究所
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佐々木 博美
Research Institute for Pharmacology
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松崎 豊
Research INstitute for Pharmacology
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松崎 珠絵
Research Institute for Pharmacology
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池谷 幸信
Tsumura Central Research Laboratories Tsumura & Co.
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三橋 博
ツムラ生物・化学研所
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Ikeya Y
Tsumura Central Research Laboratories Tsumura & Co.
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細谷 栄吉
Department Of Pharmacology:(present Address)kanebo Company
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松崎 珠絵
Tsumura Central Research Laboratories Tsumura & Co.
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松崎 豊
株式会社ツムラ薬理研究所
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