27 ガガイモ科植物の成分 : Glycocynanchogeninの構造 ^<13>C Pulse Fourier Transform(PFT)NMRのC/D cis polyoxypregnaneの構造決定への応用
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概要
- 論文の詳細を見る
The structures of five new polyoxypregnane derivatives: caudatin, ikemagenin, isoikemagenin, Gagaminin and Glycocynanchogenin which had been isolated from the aglycone fraction of Cynanchum caudatum Max. (Asclepiadaceae) besides four other known substances: lineolon isolineolon, deacylmetaplexigenin and sarcostin, were discussed. On the bases of chemical and physico-chemical evidences, above new compounds have been concluded to have the structures Ia, IIa, IIb, IIIa and IVa respectively. We have measured the ^<13>C nmr spectra of a series of C/D cis polyoxypregnanes and have been able to make satisfactory assignments of nearly all of the resonances by auxiliary techniques such as noise-modulated total proton decupling, off resonance proton decoupling, hydroxyl acylation effects on chemical shifts, solvent effects and substituent influences in analogous compounds. The ^<13>C nmr were for more informative than proton nmr for structural analysis of this series.
- 天然有機化合物討論会の論文
- 1972-10-01
著者
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三橋 博
北大薬学部
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林 紘司
北大薬
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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林 紘司
Tsumura Central Research Laboratories Tsumura & Co.
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松下 和弘
日本電子aid研
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山岸 喬
北大薬
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鬼山 律子
北大薬
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今成 司
日本電子AID研
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三橋 博
北大薬学科
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