17 C/D cis-Polyhydroxy-pregnane型化合物,Tomentogenin,Marsdenin,Stephanol,の構造について
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概要
- 論文の詳細を見る
C/D cis polyhydroxy-pregnanes with the 1,2-vicinal glycol have been isolated from Digitalis spp., Adonis spp., and from many genera in Asclepiadacae. This report deals with the synthesis of tomentogenin from hecogenin and with the structure of marsaenin and stephanol, isolated from Marsdenia cundurango Reich and Stephanotis japonica Makino, respectively. Partial synthesis of tomentogenin isolated from Marsdenia tomentosa Dence, was achieved by the reduction of the bisepoxide (V), and this key intermediate(V) was prepared by the introduction of epoxide to the β position of 3β,12β-diacetoxy-14β,15β-epoxy-5α-pregn-16-en-20-one(IV). Marsdenin was given the structure of 3β,8β,11α,12β,14β-pentahydroxy-17-isopregn-5-en-20-one(XI) and stephanol was assigned that of 3β,8β,11α,12β,14β,17β,20-heptahydroxy-pregn-5-ene(XV), on the bases of chemical and physical evidences.
- 天然有機化合物討論会の論文
- 1969-09-01
著者
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三橋 博
北大薬学部
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林 紘司
北大薬
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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林 紘司
Tsumura Central Research Laboratories Tsumura & Co.
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三橋 博
北大薬学科
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福岡 正道
北大薬学科
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福岡 正道
National Institute of Hygienic Sciences
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