Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor α on Estrogen Receptor α Activation under Hypoxic Conditions
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概要
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Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) α expression and transactivation. We investigated the effect of blocking ER degradation on ERα-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132. Pretreatment with MG132 blocked hypoxia-induced degradation of ERα protein. Our data imply that ERα proteasomal inhibition is linked to receptor transactivation under hypoxia.
著者
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LEE Young
College of Veterinary Medicine, Seoul National University
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CHO Jung
College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejo
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Cho Jung
College Of Engineering Institute Of Biotechnology Department Of Bioscience And Biotechnology Sejong
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Lee Young
College Of Bioscience Institute Of Biotechnology Department Of Bioscience And Biotechnology Sejong U
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Park Yeo
College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sej
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Koo Young
College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sej
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Lee Young
College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University
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Cho Jung
College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University
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Park Yeo
College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University
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