Inhibition of Nuclear Factor-κB Activation by 2',8"-Biapigenin(Pharmacognosy)

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概要

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• Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an oriental medicine, which has been reported to inhibit the production of proinflammatory cytokines and cause cell cycle arrest. We isolated 2',8"-biapigenin from S. tamariscina and investigated whether it modulates iNOS and COX-2 expressions in Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). We found that 2',8"-biapigenin blocked the transactivations of iNOS and COX-2 genes via the inactivation of nuclear factor-KB by preventing the nuclear translocation of p65. Hence, it may be possible to develop S. tamariscina extracts or 2',8"-biapigenin as a useful agent for cancer chemoprevention or for the treatment of inflammatory diseases.

• 公益社団法人日本薬学会の論文
• 2006-05-01

著者

• Kang Keon

  Bk21 Project Team Chosun University : College Of Pharmacy Chosun University

• WOO Eun-Rhan

  College of Pharmacy, Chosun University

• Pokharel Yuba

  Bk21 Project Team Chosun University : College Of Pharmacy Chosun University

• POKHAREL Yuba

  College of Pharmacy, Chosun University

• YANG Jin

  College of Pharmacy, Chosun University

• LEE Song

  College of Pharmacy, Chosun University

• KANG Keon

  College of Pharmacy, Chosun University

• Woo Eun-rhan

  Coll. Of Pharmacy Chosun Univ.

• Woo Eun-rhan

  College Of Pharmacy Chosun University

• Lee Song

  College Of Pharmacy Chosun University

• Yang Jin

  College Of Pharmacy Chosun University

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