Proteomic Analysis of Bronchoalveolar Lavage Fluid Obtained from Rats Exposed to Formaldehyde

概要

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Formaldehyde is an industrial chemical used in the manufacture of building materials and household products, and is one of the major pollutants that cause “sick building syndrome.” Formaldehyde causes a wide range of toxic effects such as the formation of DNA-protein cross-links, activation of the immune system, and sensory irritation. In the present study, we investigated the effects of formaldehyde inhalation on protein levels in rat bronchoalveolar lavage fluid with a proteomics approach. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight mass spectroscopy, we identified aldo-keto reductase 1B10 as a possible biomarker for formaldehyde inhalation. This study may contribute to a better understanding of the mechanisms involved in the pathogenesis of formaldehyde exposure.