4,4'-Dihydroxybiphenyl as a New Potent Tyrosinase Inhibitor(Miscellaneous)
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概要
- 論文の詳細を見る
The color of mammalian skin is determined by many factors, for which visible ones are the degree and distribution of melanin pigmentation. Because tyrosinase, (polyphenol oxidase) is the key enzyme for melanin biosynthesis, the use of various tyrosinase inhibitors is a common practice for whitening purpose in cosmetics. In the present study, the inhibition of tyrosinase by 4,4'-dihydroxybiphenyl (44'-BP) was investigated. In addition to tyrosinase inhibiting activity, melanin biosynthesis was assessed in B16F10 melanoma cells (B16 cells). The results showed that 44'-BP exhibits a strong anti-tyrosinase activity with IC_<50>=1.91μм. The kinetic analysis of tyrosinase inhibition revealed that 44'-BP acts a competitive inhibitor (K_i=4.0×10^<-4>м at 2.5μм and K_i=2.1×10^<-5>м at 5μм). Furthermore, data on melanin biosynthesis indicated that the amount of melanin was clearly suppressed by 44'-BP.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
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Lee Ji
Department Of Dermatology And Internal Medicine Chungbuk National University
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Chung H
College Of Pharmacy Aging Tissue Bank Pusan National University
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Kim You
Department Of Internal Medicine Seoul National University College Of Medicine
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Kim You
Department Of Cosmetology Pusan Women's College
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CHUNG Hae
Department of Pharmacy, Pusan National University
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NO Jae
Department of Pharmacy, Pusan National University
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No Jae
College Of Pharmacy Aging Tissue Bank Pusan National University
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No Jae
Department Of Obstetrics And Gynecology Seoul National University College Of Medicine Seoul National
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Chung Hae
Department Of Pharmacy College Of Pharmacy:longevity Life Science And Technology Institutes Pusan Na
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Lee Ji
Department Of Advanced Materials Science And Engineering Sungkyunkwan University
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Lee Ji
Department Of Pharmacy Pusan National University
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Chung Hae
Department Of Pediatrics Chonnam National University Medical School
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Chung Hae
Department Of Kinesiology And Community Health University Of Illinois
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