Hyperin and Quercetin Modulate Oxidative Stress-Induced Melanogenesis
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概要
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Hyperin and quercetin are phenolic compounds present in fruits and vegetables that have been reported to possess strong anti-oxidative properties. Although increasing evidence strongly suggests that antioxidants suppress the melanin synthesis that is causally associated with oxidative stress, the protective actions of hyperin and quercetin against oxidative stress-induced melanogenesis have not been fully explored. To elucidate the suppressive effects of hyperin and quercetin on oxidative stress and melanin synthesis, peroxynitrite (ONOO－) scavenging activity was measured in vitro as were quantifications of melanin content, intracellular total RS, ONOO－, superoxide (•O2), nitric oxide (NO•), catalase activity and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. Results showed that in vitro, hyperin and quercetin reduced ONOO－. Additionally, hyperin and quercetin suppressed total RS, ONOO－, •O2, and NO•, catalase activity, and melanin synthesis, while they boosted the GSH/GSSG ratio in B16F10 melanoma cells (B16 cells). Therefore, I propose that hyperin and quercetin have a powerful capacity to modulate oxidative stress-induced melanogenesis.
著者
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Kim You
Department Of Cosmetology Pusan Women's College
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Jung KIM
Department of Dental Hygiene, Busan Women's College
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Kim You
Department of Chemistry, Sahmyook University
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