Antimelanogenic Activity of 3,4-Dihydroxyacetophenone : Inhibition of Tyrosinase and MITF

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概要

• 論文の詳細を見る

• 3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4-DHAP. Our data indicate that the antimelanogenic activity of 3,4-DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.

• 社団法人 日本農芸化学会の論文
• 2006-02-23

著者

• Kim Myoung

  Department Of Neurosurgery Seoul Paik Hospital Inje University College Of Medicine

• LEE Jun

  College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers

• Chung H

  College Of Pharmacy Aging Tissue Bank Pusan National University

• Chung Hae

  College Of Pharmacy Pusan National University

• Kim You

  Department Of Internal Medicine Seoul National University College Of Medicine

• Kim Myoung

  Department Of Nursing Pusan National University

• Kim You

  Department Of Cosmetology Pusan Women's College

• NO Jae

  College of Pharmacy, Aging Tissue Bank, Pusan National University

• No Jae

  College Of Pharmacy Aging Tissue Bank Pusan National University

• Chung Hae

  College Of Pharmacy Aging Tissue Bank Pusan National University

• Lee Jun

  College Of Pharmacy Aging Tissue Bank Pusan National University

• Kim Myoung

  Department Of Computer Science Kaist

• Lee Jun

  College Of Agriculture And Life Sciences Seoul National University

• Kim Myoung

  Department Of Anesthesiology Paik Hospital Inje University

• Lee Jun

  College of Agriculture and Life Science, Seoul National University, Seoul 151-742, Korea

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