Effects of Melittin on the Production of Matrix Metalloproteinase-1 and -3 in Rheumatoid Arthritic Fibroblast-Like Synoviocytes

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概要

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• Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fibroblast-like synoviocytes (FLS). Lipopolysaccharide (LPS)-stimulated MMP3 production was significantly inhibited by melittin, which also inhibited LPS-induced DNA binding by nuclear factor κB (NF-κB). Mellitin had no effect on IL-1β– or TNF-α–induced MMP1 or MMP3 production and did not decrease LPS-induced secretion of MMP1. Taken together, these findings suggest that melittin may exert its anti-rheumatoid effects, at least in part, by inhibiting MMP3 production, most likely through inhibition of NF-κB activity.

• 社団法人 日本薬理学会の論文
• 2008-01-20

著者

• CHUNG Joo-Ho

  Departments of Pharmacology, College of Medicine, Kyung Hee University

• HA Eunyoung

  Department of Biochemistry, College of Medicine, Kyung Hee University

• Ha Eunyoung

  Department Of Biochemistry And Molecular Biology College Of Medicine Kyung Hee University

• Chung Joo-ho

  Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi

• Mun Se

  Coll. Of Medicine Konkuk Univ. Kor

• NAH Seong-Su

  Division of Allergy and Rheumatology, Department of Internal Medicine, University of Ulsan College o

• MUN Se

  Department of Immunology, College of Medicine, Kunkuk University

• WON Hye-Jin

  Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University

• Mun Se

  Department Of Immunology College Of Medicine Kunkuk University

• Nah Seong-su

  Division Of Allergy And Rheumatology Department Of Internal Medicine University Of Ulsan College Of

• Won Hye-jin

  Department Of Biochemistry And Molecular Biology College Of Medicine Kyung Hee University

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