Troglitazone Increases IL-1β Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression via Enhanced Phosphorylation of IκBα in Vascular Smooth Muscle Cells from Wistar-Kyoto Rats and Spontaneously Hypertensive Rats(Pharmacology)
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概要
- 論文の詳細を見る
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists of the thiazolidinedione class are widely used for the treatment of type 2 diabetes subjects due to their ability to improve insulin resistance. Troglitazone and ciglitazone belong to the PPARγ agonists of thiazolidinediones. We report here that troglitazone but not ciglitazone increased IL-1β induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in vascular smooth muscle cell (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Potentiated expression of COX-2 and iNOS by troglitazone was inhibited by MG-132, a specific inhibitor of inhibitory factor κB (IκB) activation. Troglitazone treatment of these cells also resulted in a dosedependent increase in IL-1β induced IκBα phosphorylation. These data suggest that troglitazone is capable of increasing IL-1β induced COX-2 and iNOS expression through an IκBα dependent mechanism in VSMC from WKY and SHR.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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Choi Hyoung
Aging-associated Vascular Disease Res. Center Coll. Of Medicine Yeungnam Univ.
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Kang Young
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Choi Hyoung
Department of Pharmacology, Aging-associated Vascular Disease Research Center, College of Medicine,
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Kim Hee
Deapartment Of Microbiology Aging-associated Vascular Disease Research Center College Of Medicine Ye
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Kim Hee
Department Of Neuroscience College Of Medicine Ewha Womans University
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Choi H
Yeungnam Univ. Daegu Kor
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Choi Hyoung
Dep. Of Pharmacology Aging-associated Vascular Disease Res. Center Coll. Of Medicine Yeungnam Univ.
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Kang Young
Dep. Of Pharmacology Aging-associated Vascular Disease Res. Center Coll. Of Medicine Yeungnam Univ.
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Choi Hyoung
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Kang Young
Department Of Chemistry Sogang University
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Kang Young
Department Of Chemistry Chungbuk National University
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