Shengmai-san-Mediated Enhancement of Regenerative Responses of Spinal Cord Axons After Injury in Rats
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概要
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Shengmai-san (SMS) is a traditional Chinese medicine used to treat diverse symptoms including cardiovascular and neurological disorders. Here we investigated the effects of SMS on regenerative responses of spinal cord axons in rats that were given contusion injury at the lower thoracic level. The injury cavity was confined to a restricted area by SMS treatment, and the signals of glial scar protein chondroitin sulphate proteoglycan (CSPG) and inflammatory cell marker protein CD11β were heavily observed within the injury cavity in SMS-treated animals. Anterograde tracing of DiI-labeled corticospinal tract (CST) axons revealed increases in collateral arborization around and within the injury cavity and caudal elongation by SMS treatment. Furthermore, SMS treatment facilitated neurite elongation of dorsal root ganglion (DRG) sensory neurons that were co-cultured with non-neuronal cells prepared from injured spinal cord. Phospho-Erk1/2 was strongly induced in both spinal cord and motor cortical areas after spinal cord injury (SCI), and it was further unregulated in the motor cortex by SMS treatment. In contrast, upregulation of cell division cycle 2 (Cdc2) production by SMS treatment was limited to a local, SCI area. These data suggest that SMS may play an active role in regenerative responses and facilitate axonal regrowth after SCI.
- 2009-08-20
著者
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Kim Yoon
Department of Obstetrics and Gynecology, Microbiology and Immunology, Chonnam National University Me
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SEO Tae
Department of Oriental Medicine, Daejeon University
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BAEK Kyungmin
Department of Oriental Medicine, Daejeon University
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KWON Ku-Birm
Department of Oriental Medicine, Daejeon University
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LEE Sang-Ik
Department of Oriental Medicine, Daejeon University
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LIM Jong-Soon
Department of Oriental Medicine, Daejeon University
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SEOL In
Department of Oriental Medicine, Daejeon University
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SEO Young-Bae
Department of Oriental Medicine, Daejeon University
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NAMGUNG Uk
Department of Oriental Medicine, Daejeon University
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Lim Jong-soon
Department Of Oriental Medicine Daejeon University
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Namgung Uk
Department Of Oriental Medicine Daejeon University
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Lee Sang-ik
Department Of Oriental Medicine Daejeon University
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Kwon Ku-birm
Department Of Oriental Medicine Daejeon University
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Seo Young-bae
Department Of Oriental Medicine Daejeon University
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Baek Kyungmin
Department Of Oriental Medicine Daejeon University
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Seol In
Department Of Oriental Medicine Daejeon University
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Seo Tae
Department Of Oriental Medicine Daejeon University
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Seo Tae
Department Of Cardiovascular Medicine Chonnam National University Hospital Chonnam National Universi
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Kim Yoon
Department Of Oriental Medicine Daejeon University
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Kim Yoon
Department Of Anesthesiology And Pain Medicine Chungnam National University Hospital
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Seo Young-Bae
Department of Herbology, College of Oriental Medicine, Daejeon University
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