Pilocarpine-Induced Seizure Susceptibility in Rats Following Prenatal Methylazoxymethanol Treatment(Pharmacology)
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概要
- 論文の詳細を見る
Several rodent models of cortical malformation are available for the study of cellular mechanisms associated with early-onset epilepsy, but few are associated with spontaneous seizures. We examined the effect of pilocarpine on the spontaneous seizure development and excitability of the CAl pyramidal cells of rats after prenatal treatment with methylazoxymethanol (MAM). Pilocarpine induced status epilepticus (SE) onset latency was greater for normal rats than for MAM-treated rats. After several days of normal behavior following pilocarpine treatment, the duration of spontaneous seizures were greater in MAM-pilocarpine rats than in normal-pilocarpine rats. Compared with the normal rats, electrical stimulation of afferent fibers resulted in more robust population responses in the CAl region in all groups. At interstimulus intervals of 30 and 70ms, the MAM-pilocarpine rats displayed a decrease in paired pulse inhibition versus the conventional MAM rats. A loss of somatostatin- and parvalbumin-immunoreactive neurons was apparent in the normal-pilocarpine rats, MAM-pilocarpine rats, and conventional MAM rats. These results indicate that pilocarpine induces spontaneous seizures and hyperexcitability in MAM-pilocarpine rats.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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LEE Maan-Gee
Department of Pharmacology, School of Medicine, Kyungpook National University
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Choi In
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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Choi In
Department Of Pharmacology School Of Dentistry Kyungpook National University
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Lee Maan
Department Of Pharmacology School Of Medicine Kyungpook National University
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Lee Maan-gee
Department Of Pharmacology School Of Medicine Kyungpook National University
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Choi Byung
Department Of Pediatrics St Mary's Hospital The Catholic University Of Korea
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Choi Byung
Department Of Pharmacology School Of Dentistry Kyungpook National University
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CHOI In-Sun
Department of Pharmacology, School of Dentistry, Kyungpook National University
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CHO Jin-Hwa
Department of Pharmacology, School of Dentistry, Kyungpook National University
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CHO Jin
Department of Dental Pharmacology, College of Dentistry, Kyungpook National University
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Cho Jin
Department Of Pharmacology School Of Dentistry Kyungpook National University
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Choi Byung
Department Of Civil Engineering Sungkyunkwan University
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Cho Jin
Department Of Animal Resource And Sciences Dankook University
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