Stereochemical Elucidation of the Reaction Products of α-Narcotine with Ethyl Chloroformate

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概要

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• α-Narcotine (1) was treated with ethyl chloroformate by refluxing in dichloromethane to afford six products, which were separated by preparative high-performance liquid chromatography (HPLC). Their stereochemistry and structures were elucidated. This reaction proceeded initially to the chloro-carbamates and successively to the corresponding carbinols. In addition, N-desmethyl-N-carbethoxynarcotine (3), found in the HPLC chromatogram, was identified by direct comparison with synthetic 3; this compound had caused difficulty in our previous mass spectrometric investigations.

• 公益社団法人日本薬学会の論文
• 1995-11-15

著者

• LEE Dong-Ung

  Department of Biotechnology, College of Natural Science, Dongguk University

• Lee Dong-ung

  Department Of Biochemistry Dongguk University

• EIBLER Ernst

  Institute of Pharmacy, University of Regensburg

• MAYER Klaus

  Institute of Pharmacy, University of Regensburg

• WIEGREBE Wolfgang

  Institute of Pharmacy, University of Regensburg

• Mayer Klaus

  Institute Of Pharmacy University Of Regensburg

• Eibler Ernst

  Institute Of Pharmacy University Of Regensburg

• Wiegrebe Wolfgang

  Institute Of Pharmacy University Of Regensburg

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