In Vitro Antimicrobial Activity and the Mode of Action of Indole-3-Carbinol against Human Pathogenic Microorganisms(Microbiology)
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概要
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Indole-3-carbinol (13C) is a naturally occurring constituent of cruciferous vegetables. The aim of this study was to assess the in vitro antimicrobial activity of 13C and its mode of action. By using an NCCLS broth microdilution assay, the activity of 13C was evaluated against human pathogenic microorganisms including clinically isolated antibiotic-resistant bacterial strains. The results indicated that 13C exhibited broad spectrum antimicrobial activities. To elucidate the physiological changes of the fungal cells induced by 13C, we performed a flow cytometric analysis for a cell cycle. The results showed that 13C arrested the cell cycle at the G_2/M phase in Candida albicans. To understand the antifungal mode of action of 13C, the change in the membrane dynamics was monitored by using fluorescence changing experiments against C. albicans. The results suggest that 13C may exert antifungal activity by disrupting the structure of the cell membrane. The present study indicates that 13C has considerable antimicrobial activity, deserving further investigation for clinical applications.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
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Sung Woo
Dep. Of Microbiology Coll. Of Natural Sciences Kyungpook National Univ.
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Lee Dong
Dep. Of Microbiology Coll. Of Natural Sciences Kyungpook National Univ.
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Lee Dong
School Of Life Sciences & Biotechnology College Of Natural Sciences Kyungpook National Universit
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SUNG Woo
Department of Microbiology, College of Natural Sciences, Kyungpook National University
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Lee Dong
Department Of Aerospace Engineering Chonbuk National University
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Sung Woo
Department Of Microbiology College Of Natural Sciences Kyungpook National University
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