Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles
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概要
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A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150—170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.
著者
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Lee Sangyeop
Department Of Applied Chemistry Hanyang University
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Kang Myung
College of Pharmacy, Chung-Ang University
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Kim Bo
College of Pharmacy, Chung-Ang University
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Eum Jae
College of Pharmacy, Chung-Ang University
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Park Sang
College of Pharmacy, Chung-Ang University
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Kang Min
College of Pharmacy, Chung-Ang University
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Oh Chil
College of Medicine, Korea University
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Choo Jaebum
Department of Bionano Engineering, Hanyang University
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Choi Young
College of Pharmacy, Chung-Ang University
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Choo Jaebum
Department Of Applied Chemistry Hanyang University
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Choi Young
College Of Pharmacy Seoul National University
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Park Sang
College of Oriental Medicine, Kyung Hee University
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