Anti-Inflammatory Effects of Gomisin N, Gomisin J, and Schisandrin C Isolated from the Fruit of Schisandra chinensis
スポンサーリンク
概要
- 論文の詳細を見る
Schiandra chinensis is a well-known Chinese traditional medicine for the treatment of hepatic disease. In this study, we investigated whether the nine major compounds of Schiandra chinensis could be applied to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Among the nine lignans, three, gomisin J, gomisin N, and schisandrin C, were found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells. These three lignans showed low cytotoxic effects in Raw 264.7 cells. Pre-treatment of Raw 264.7 cells with gomisin J, gomisin N, or schisandrin C reduced the expression of mRNA and the secretion of pro-inflammatory cytokines. These inhibitory effects were found to be caused by blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal–regulated kinases 1 and 2 (ERK 1/2), and c-Jun N-terminal kinase (JNK) phosphorylation.
- 社団法人 日本農芸化学会の論文
- 2010-02-23
著者
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Pan Cheol-ho
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Lee Hee
Natural Products Res. Center Korea Inst. Of Sci. And Technol. Gangneung Inst.
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Lee Hee
Natural Products Research Center Korea Institute Of Science And Technology
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Kim Chul
Natural Products Res. Center Korea Inst. Of Sci. And Technol. Gangneung Inst.
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Um Byung
Natural Products Res. Center Korea Inst. Of Sci. And Technol. Gangneung Inst.
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Lee Hee
Natural Products Res. Center Gangneung Inst. Korea Inst. Of Sci. And Technol.
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Lee Jae
Department Of Acupuncture & Moxibustion College Of Oriental Medicine
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Kim Young
Department Of Biology Education College Of Education Chungbuk National University
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Pan Cheol-ho
Natural Products Research Center Korea Institute Of Science And Technology Gangneung Institute
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Oh Su-yeon
Department Of Biology Education College Of Education Chungbuk National University
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Lee Jae
Department Of Biology Education College Of Education Chungbuk National University
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BAE Deok
Department of Biology Education, College of Education, Chungbuk National University
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Bae Deok
Department Of Biology Education College Of Education Chungbuk National University
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Kim Chul
Natural Products Res. Center Gangneung Inst. Korea Inst. Of Sci. And Technol.
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