Successful Treatment of Renal Cell Carcinoma With Mediastinal Lymph Node Metastasis by Interleukin-2 : A case report
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概要
- 論文の詳細を見る
A 57-year-old woman presented to our hospital with macrohematuria. Renal cell carcinoma (RCC) of the left kidney with bilateral pulmonary and mediastinal lymph node metastases was diagnosed. Radical nephrectomy was performed. Pathological examination confirmed the diagnosis of RCC (pT2pN0M1), so immunotherapy was performed using interleukin-2 (IL-2). The mediastinal lymph node metastases disappeared completely after 5 months of immunotherapy. Investigation of immunological parameters showed an increase of CD8-positive T cells (CD8) and a decrease of CD14-positive cells (CD14), leading to a marked increase of the CD8/CD14 ratio. Although her pulmonary metastases are unchanged, the mediastinal metastases still show complete remission at 14 months postoperatively. The CD8/CD14 ratio may have potential as a new marker for monitoring the response of RCC to immunotherapy and selecting suitable patients for such therapy.
- 東海大学の論文
著者
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TERACHI Toshiro
Department of Urology, Kyoto University Graduate School of Medicine
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Terachi Toshiro
Department Of Urology Tokai University School Of Medicine
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Terachi Toshiro
東海大学 医学部病理学
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Tokunaga Masatoshi
Department Of Urology Tokai University School Of Medicine
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Tokunaga Masatosi
東海大学 医学部泌尿器科学
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Tokunaga Masatoshi
東海大学医学部附属大磯病院 泌尿器科学
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MASUDA Aiichiro
Department of Oiso Hospital, Tokai University
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Masuda Aiichiro
東海大学 医学部泌尿器科学
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Masuda Aiichiro
Department Of Oiso Hospital Tokai University
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Masuda Aiichiro
Department Of Urology Tokai University School Of Medicine Tokyo Hospital
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MUKAI Masaya
Department of Surgery, Tokai University Oiso Hospital
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NAKAMURA Hideyuki
Department of Medical Information, Schering-Plough K.K
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IWAKI Koji
SRL, Inc.
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Iwaki Koji
Srl Inc.
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Terachi Toshiro
Department Of Urology Faculty Of Medicine Kyoto University
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Mukai Masaya
Department Of Clinical Immunohematology Sapporo City General Hospital
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Mukai Masaya
Department Of Surgery Tokai University Oiso Hospital
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Nakamura Hideyuki
Department Of Medical Information Schering-plough K.k
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Nakamura Hideyuki
Department Of Geological Sciences Faculty Of Science Naruto University Of Education
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