Drug-induced Thrombotic Thrombocytopenic Purpura Successfully Treated with Recombinant Human Soluble Thrombomodulin
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概要
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A 61-year-old woman with recurrent non-small cell lung cancer presented with thrombocytopenia, microangiopathic hemolytic anemia, neurological abnormalities, renal failure and a fever that appeared during chemotherapy with gemcitabine and bevacizumab. She was diagnosed with drug-induced thrombotic thrombocytopenic purpura (TTP). After the discontinuation of chemotherapy, the administration of recombinant human soluble thrombomodulin and fresh-frozen plasma rapidly ameliorated the TTP. Hypertension preceded the onset of TTP and required the administration of quadruple therapy on admission. However, after three months, the hypertension was controllable without anti-hypertensive drugs. Twelve months later, the ninth course of vinorelbine was administered safely, preventing the patient's lung cancer from progressing.
著者
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TAKAHASHI Ryo
Department of Mathematical Sciences Faculty of Science Shinshu University
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Takeda Yoshito
Department Of Respiratory Medicine Allergy And Rheumatic Diseases Osaka University Graduate School O
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Kida Hiroshi
Department Of Cardiology Kanazawa National Hospital
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Fujimura Yoshihiro
Department Of Blood Transfusion Medicine Nara Medical University
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Tachibana Isao
Department Of Molecular Medicine Osaka University Graduate School Of Medicine
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Kijima Takashi
Department Of Molecular Medicine Osaka University Graduate School Of Medicine
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Kumanogoh Atsushi
Department Of Immunopathology Immunology Frontier Research Center (ifrec) Research Institute For Mic
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Matsumoto Masanori
Department Of Anesthesiology Nagasaki University School Of Medicine
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Nagatomo Izumi
Department Of Respiratory Medicine Allergy And Rheumatic Diseases Osaka University Graduate School Of Medicine
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Hirata Haruhiko
Department Of Respiratory Medicine Allergy And Rheumatic Diseases Osaka University Graduate School Of Medicine
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Inoue Kouji
Department of Cardiology, Ogikubo Hospital Cardiovascular Center
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Otani Yasushi
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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Kijima Takashi
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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Inoue Kouji
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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Takeda Yoshito
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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Nishijima Yu
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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Himeno Aiko
Postgraduate Medical Training Center, Osaka University Hospital, Japan
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Kida Hiroshi
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Japan
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