Influenza A Infection Triggers Thrombotic Thrombocytopenic Purpura by Producing the Anti-ADAMTS13 IgG Inhibitor
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概要
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A 68-year-old Japanese woman infected with influenza A developed thrombotic thrombocytopenic purpura (TTP) 2 days after having a fever. Routine laboratory tests on admission suggested a diagnosis of disseminated intravascular coagulation. However, ADAMTS13 assays showed an extremely low level of plasma ADAMTS13 activity with a high titer of anti-ADAMTS13 inhibitor (IgG). Despite high-dose methylprednisolone therapy with daily plasma exchange for 3 consecutive days, the patient died of pulmonary congestion complicated by cardiac failure. Our experience here provides the first evidence that influenza A infection is sufficient to trigger TTP by producing the anti-ADAMTS13 IgG inhibitor.
著者
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Matsumoto Masanori
Department Of Blood Transfusion Medicine Nara Medical University
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FUJIMURA Yoshihiro
Department of Blood Transfusion Medicine, Nara Medical University
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Kosugi Nobuharu
Department of Internal Medicine, Numazu City Hospital
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Tsurutani Yuya
Department of Internal Medicine, Numazu City Hospital
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Isonishi Ayami
Department of Blood Transfusion Medicine, Nara Medical University
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Hori Yuji
Department of Blood Transfusion Medicine, Nara Medical University
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Kosugi Nobuharu
Department Of Hematology Numazu City Hospital
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Fujimura Yoshihiro
Department Of Blood Transfusion Medicine Nara Medical University
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Tsurutani Yuya
Department Of Clinical Cell Biology And Medicine Chiba University Graduate School Of Medicine
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Hori Yuji
Department Of Blood Transfusion Medicine Nara Medical University
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Isonishi Ayami
Department Of Blood Transfusion Medicine Nara Medical University
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Matsumoto Masanori
Department Of Anesthesiology Nagasaki University School Of Medicine
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