Immobilization of Arg-Gly-Asp (RGD) Sequence in Sugar Containing Copolymer for Culturing of Pheochromocytoma (PC12) Cells (MEDICAL BIOTECHNOLOGY)
スポンサーリンク
概要
- 論文の詳細を見る
A copolymer that included a Gly-Arg-Gly-Asp-Ser (GRGDS) sequence and sugar moieties was synthesized to culture pheochromocytoma cells (PC12). PC12 cells attached to poly(N-p-vinylbenzyl-D-maltonamide-co-6-(p-vinylbenzamido)-hexanoic acid-g-GRGDS) [p(VMA-co-VBGRGDS)]-coated dishes showed greater proliferation than on other polymer-coated surfaces. Enhancement in cell growth correlated with the ability of soluble Arg-Gly-Asp (RGD) to inhibit cell adhesion to surfaces coated with p(VMA-co-VBGRGDS). This method for promoting cell proliferation may be useful for the culturing of anchorage-dependent cells. Furthermore, about 80% greater dopamine secretion from PC12 cells was produced with the p(VMA-co-VBGRGDS) as compared with PC12 cells on unmodified surfaces.
- 社団法人日本生物工学会の論文
- 2004-03-25
著者
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Lee K
College Of Pharmacy Sungkyunkwan University
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Lee Kang
韓国
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Park K‐h
Seoul National Univ. Seoul Kor
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Na Kun
College Of Pharmacy Chosun University
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Na K
Department Of Pharmaceutics And Pharmaceutical Chemistry University Of Utah
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LEE Kang
College of Pharmacy, Sungkyunkwan University
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Lee Kang
College Of Pharmacy Sungkyunkwan University
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Park K‐h
School Of Medical Engineering Ajou University
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PARK KEUN-HONG
School of Medical Engineering, Ajou University
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NA KUN
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah
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Na Kun
Department Of Biotechnology The Catholic University Of Korea
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