The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract
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概要
- 論文の詳細を見る
Interstitial cells of Cajal (ICCs) are a fundamental component of the pacemaker apparatus of the gastrointestinal (GI) tract. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal smooth muscle. The pacemaker current that generates slow waves is initially due to a voltage-independent, Ca^<2+>-inhibited, non-selective cationic conductance in ICC. The classical transient receptor potential (TRPC) channel 4 was suggested as a molecular candidate for the nonselective cation channel (NSCC) responsible for the pacemaker activity. We have shown that TRPC4-/- mice display normal slow waves and suggest that TRPC4 might be an essential component of the NSCC activated by muscarinic stimulation. Finally, we suggest that TRPM7 is the molecular candidate for the NSCC responsible for pacemaker activity in ICCs on the basis of electrophysiological, molecular biological, and immunohistochemical experiments.
- 日本平滑筋学会の論文
著者
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Kim Ki
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res
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So Insuk
Department of Physiology, Seoul National University College of Medicine
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Kim Ki
韓国
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Kim K
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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Kim Byung
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan, University School of Medici
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So Insuk
韓国
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So Insuk
Department Of Physiology Seoul National University College Of Medicine
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So Insuk
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Kim Byung
Div. Of Longevity And Biofunctional Medicine Pusan National Univ. School Of Korean Medicine
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Kim Ki
Department Of Physiology School Of Medicine Gachon University Of Medicine And Science
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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Kim Byung
Department Of Applied Mathematics College Of Applied Science Kyung Hee University
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Kim Byung
Department Of Aerospace Engineering School Of Engineering Nagoya University
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