Serum Uric Acid as an Independent and Incremental Prognostic Marker in Addition to N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Acute Myocardial Infarction
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概要
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Background: There are limited data regarding the prognostic value of serum uric acid (UA) after acute myocardial infarction (AMI). We investigated whether UA predicts the prognosis independently and whether it has an incremental value to other factors, including N-terminal Pro-B-type natriuretic peptide (NT-ProBNP), in patients with AMI. Methods and Results: This study included 850 patients with AMI who were enrolled in the Korea AMI Registry from a single center. A major adverse cardiovascular event (MACE) was defined as a composite of death, recurrent myocardial infarction, and revascularization. During 6-month follow-up, MACE developed in 109 (12.8%). UA was higher in patients with MACE than in those without MACE (6.5±2.4mg/dl vs. 5.4±1.8mg/dl, P<0.001). In the Cox-proportional hazard model, UA (hazard ratio [HR] 1.297, 95% confidence interval [CI] 1.075-1.565, P=0.007) was an independent predictor for 6-month MACE in addition to log NT-ProBNP (HR 2.362, 95%CI 1.007-5.539, P=0.048), heart rate (HR 1.028, 95%CI 1.009-1.047, P=0.004) and 3-vessel disease (HR 3.278, 95%CI 1.378 to 7.797, P=0.007). UA had incremental prognostic value to conventional risk factors (chi-square=8, P=0.005), and to the combination of conventional factors and NT-ProBNP (chi-square=10, P=0.002). Conclusions: UA is an independent predictor of short-term prognosis and has incremental value to NT-ProBNP in patients with AMI. (Circ J 2011; 75: 1440-1447)
- 2011-05-25
著者
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Chae Shung-chull
Kyungpook National University Hospital
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Jun Jae-eun
Kyungpook National University Hospital
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Park Sun
Department Of Agricultural Chemistry The University Of Tokyo
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Park Hun
Department Of Biomedical Engineering School Of Medicine Kyung Hee University
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Lee Sang
Department Of Advanced Materials Science And Engineering Mokpo National University
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Cho Yongkeun
Department of Internal Medicine, Kyungpook National University Hospital
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Heo Jungho
Kosin University Gospel Hospital
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Lee Soon
Kyungpook National University Hospital
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Yang Dong
Department Of Computer Science Tokyo Institute Of Techonology
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Jun Jae
Department Of Internal Medicine Kyungpook National University Hospital
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Park Hun-sik
Kyungpook National University Hospital
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Chae Shung
Department Of Internal Medicine Kyungpook National University Hospital
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Park Hun
Department Of Internal Medicine Kyungpook National University Hospital
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Cho Yongkeun
Department Of Internal Medicine Kyungpook National University Hospital
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Yang Dong
Department Of Internal Medicine Kyungpook National University Hospital
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Han Juyup
Department Of Internal Medicine Kyungpook National University Hospital
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Lee Jang
Department Of Internal Medicine Kyungpook National University Hospital
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Park Sun
Department Of Internal Medicine Kyungpook National University Hospital
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BAE Myung
Department of Internal Medicine, Kyungpook National University Hospital
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Bae Myung
Department Of Internal Medicine Kyungpook National University Hospital
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Jun Jae-eun
Department Of Internal Medicine Kyungpook National University Hospital
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LEE Jang
Department of Control and Instrumentation Engineering, and Automatic Control Research Center Seoul National University
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LEE Sang
Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung Hee University
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Lee Jang
Department of Biological Sciences, Konkuk University
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