Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress

スポンサーリンク

概要

• 論文の詳細を見る

• Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-β1)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.

• 2011-05-23

著者

• Jung Kyung

  Department Of Chemistry Advanced Materials Chemistry Research Center Korea University

• Lee Chongmu

  Department Of Materiais Science And Engineering Inha University

• HONG Sang-Won

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• LEE Hee-Seung

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• ZHENG Hong-Mei

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• HONG Soon-Sun

  Department of Biomedical Sciences and NCEED, School of Medicine, Inha University

• Choi Myung-joo

  Department Of Biomedical Sciences And Nceed School Of Medicine Inha University

• Jung Kyung

  Department Of Biomedical Sciences And Nceed School Of Medicine Inha University

• Zheng Hong-mei

  Department Of Biomedical Sciences And Nceed School Of Medicine Inha University

• Hong Sang-won

  Department Of Biomedical Sciences And Nceed School Of Medicine Inha University

• Lee Hee-seung

  Department Of Biomedical Sciences And Nceed School Of Medicine Inha University

関連論文

• Influence of the aluminum and indium concentrations on the electrical resistivity and transmittance properties of InAlZnO thin films
• Influence of the anodization process conditions and the microstructure on the photothermal effect of porous silicon used as a therapeutic agent in cancer thermotherapy
• Effect of Charge-transporting Molecules on Electrophosphorescence in a Device Fabricated Using Third-generation Dendrimer Encapsulated Tris[2-benzo[b]thiophen-2-ylpyridyl]iridium Complex
• Suppressive Effect of Punica granatum on the Production of Tumor Necrosis Factor (Tnf) in BV2 Microglial Cells(Pharmacology)
• Physical Properties of Highly Conformal TiN Thin films Grown by Atomic Layer Deposition
• Influence of the annealing atmosphere on the photoluminescence of ZnSe-core/In2O3-shell nanowires
• Preservative Effect of Electrolyzed Reduced Water on Pancreatic β-Cell Mass in Diabetic db/db Mice(Biochemistry)
• Effects of Rapid Thermal Annealing after Plasma H_2 Pretreatment of the Copper Seed Layer Surface on Copper Electroplating : Semiconductors
• Effects of Post-Deposition Annealing on the Copper Films Electrodeposited on the ECR Plasma Cleaned Copper Seed Layer
• The Removal of Intentionally Contaminated Cu Impurities on Si Substrate Using Remote H-plasma Treatments
• Chemical Vapor Deposition of TiN Films from Tetrakis(ethylmethylamido)titanium and Ammonia
• ORS-01 Design of the Optical Path for Small Form Factor Optical Disk Drive
• Betaine Modulates Age-Related NF-κB by Thiol-Enhancing Action(Biochemistry)
• Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress
• The Suppressive Effect of β-Glucan on the Production of Tumor Necrosis Factor-Alpha in BV2 Microglial Cells
• Enhancement of Ru Nucleation in Ru-Metal Organic Chemical Vapor Deposition by Electron Cyclotron Resonance Plasma Pretreatment
• Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress
• Effects of Process Parameters on the Deposition Rate, Hardness, and Corrosion Resistance of Tungsten Carbide Coatings Deposited by Reactive Sputtering
• Virtual Reality Reflection Therapy Improves Motor Recovery and Motor Function in the Upper Extremities of People with Chronic Stroke
• Thermal Stability Enhancement of Cu Interconnects by Employing a Self-aligned MgO Layer Obtained From a Cu(Mg) Alloy Film
• Physical Properties of Highly Conformal TiN Thin films Grown by Atomic Layer Deposition

もっと見る 閉じる

スポンサーリンク