Relationship between Estrogen Receptor-Binding and Estrogenic Activities of Environmental Estrogens and Suppression by Flavonoids(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
In this study, we investigated the estrogenic activity of environmental estrogens by a competition binding assay using a human recombinant estrogens receptor (hERβ) and by a proliferation assay using MCF-7 cells and a sulforhodamine-B assay. In the binding assay, pharmaceuticals had a stronger binding activity to hERβ than that of some phytoestrogens (coumestrol, daidzein, genistein, luteolin, chrysin, flavone, and naringenin) or industrial chemicals, but phytoestrogens such as coumestrol had a binding activity as strong as pharmaceuticals such as 17α-ethynylestradiol (EE), tamoxifen (Tam), and mestranol. In the proliferation assay, pharmaceuticals such as diethylstilbestrol, EE, Tam, and clomiphene, and industrial chemicals such as 4-nonylphenol, bisphenol A, and 4-dihydroxybiphenyl had a proliferation-stimulating activity as strong as 17β-estradiol (ES). In addition, we found that phytoestrogens such as coumestrol, daidzein, luteolin, and quercetin exerted a proliferation stimulating activity as strong as ES. Furthermore, we examined the suppression of proliferation-stimulating activity, induced by environmental estrogen, by flavonoids, such as daidzein, genistein, quercetin, and luteolin, and found that these flavonoids suppressed the induction of the proliferation-stimulating activity of environmental estrogens. The suppressive effect of flavonoids suggests that these compounds have anti-estrogenic and anti-cancer activities.
- 社団法人日本農芸化学会の論文
- 2002-07-23
著者
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YAMADA Koji
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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TACHIBANA Hirofumi
Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Tachibana Hirofumi
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Han Dal-ho
Department Of Environmental Toxicology University Of California
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DENISON Michael
Department of Environmental Toxicology, University of California
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Denison M
Department Of Environmental Toxicology University Of California
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Denison Michael
Department Of Environmental Toxicology University Of California
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Yamada Koji
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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