Induction of Atherosclerosis in Brown Norway Rats by Immunization with Ovalbumin
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概要
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A study was carried out to establish an animal model that would be suitable for evaluating the role of the diet in immune cell-mediated atherogenesis. Brown Norway rats were initially treated with hypervitamin D_2 for 4 days and then fed on an atherogenic diet for 3 months, during which period the rats were either immunized with ovalubumin plus Al (OH)_3 (OVA group) or with Al (OH)_3 alone (control group) every 3 weeks. Aortic lesions were mainly composed of foam cells, the lesions evaluated by the intimal thickness of the ascending aorta being more severe in the OVA group than in the control group. The OVA group, in comparison with the control group, showed prominently increased serum levels of OVA-specific IgG and rat chymase, an indicator of mast cell degranulation. The intimal thickness was positively correlated with the level of chymase. Immunization had no effect on the serum lipid levels. These results support the hypothesis that mast cells play a role in the early stage of atherosclerosis and suggest that this animal model could be useful for evaluating the role of the diet in immune-related atherogenesis.
- 1999-02-23
著者
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IMAIZUMI Katsumi
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
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NISHIZONO Shoko
Laboratory of Nutrition Chemistry, Department of Food Science and Technology, Faculty of Agriculture
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Imaizumi Katsumi
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
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ADAN Yosef
Laboratory of Nutrition Chemistry, Department of Food Science and Technology, Faculty of Agriculture
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Adan Yosef
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
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Nishizono Shoko
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
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KUSABA Mioko
Laboratory of Nutrition Chemistry, Department of Food Science and Technology, Faculty of Agriculture
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Kusaba M
Kyushu Univ. Fukuoka Jpn
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Imaizumi Katsumi
Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture
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