Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols: Comparison with Wistar Rats
スポンサーリンク
概要
- 論文の詳細を見る
Stroke-prone spontaneously hypertensive rats (SHRSP) deposit plant sterols in their bodies and have a mutation in ATP binding cassette transporter G5 (Abcg5). Lymphatic recovery rates of campesterol and sitosterol in SHRSP rats were comparable to those in Wistar rats, a strain that does not deposit plant sterols in the body and has no mutation in Abcg5. Higher absorption of stigmasterol and sitostanol was observed in SHRSP rats than in Wistar rats, but the differences between SHRSP and Wistar rats were quite small, because the absorbed amounts of these two sterols were much lower than those of campesterol and sitosterol. The in situ uptake of 3H-sitosterol and 14C-cholesterol solubilized in the bile salt micelle into intestinal mucosa was comparable between SHRSP and Wistar rats. These observations suggest that a mutation in Abcg5 does not greatly influence intestinal absorption of plant sterols in SHRSP rats, at least in comparison with Wistar rats.
著者
-
IKEDA Ikuo
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku Univers
-
HAMADA Tadateru
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
-
IMAIZUMI Katsumi
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
-
Hamada Tadateru
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
-
Hamada Tadateru
東北大学 農学研究科生体分子機能学
-
GOTO Hitomi
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
-
Goto Hitomi
九州大学 農学研究科栄養化学分野
-
Kodama Yoko
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
-
YOSHIDA Takeshi
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
関連論文
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- Structured Triacylglycerol Containing Medium-Chain Fatty Acids in sn-1(3) Facilitates the Absorption of Dietary Long-Chain Fatty Acids in Rats
- Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
- Effects of Dietary Fats and Curcumin on IgE-Mediated Degranulation of Intestinal Mast Cells in Brown Norway Rats
- Effects of Glyco- and Tauro-Cholic and Chenodeoxycholic Acids on Lymphatic Absorption of Micellar Cholesterol and Sitosterol in Rats
- Effects of Xylooligosaccharides on Blood Glucose, Serum and Liver Lipids and Cecum Short-chain Fatty Acids in Diabetic Rats(Food & Nutrition)
- Influence of Saturated and Polyunsaturated Egg Yolk Phospholipids on Hyperlipidemia in Rats(Food & Nutrition)
- Comparison of Effects of Dietary Unesterified and Esterified Plant Sterols on Cholesterol Absorption in Rats
- Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
- Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
- Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats(Food & Nutrition Science)
- Intestinal Absorbability of Wheat Allergens, Subunits of a Wheat α-Amylase Inhibitor, Expressed by Bacteria(Food & Nutrition Science)
- Concentration of Serum Lipids and Aortic Lesion Size in Female and Male Apo E-Deficient Mice Fed Docosahexaenoic Acid
- Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats
- Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
- Prevention of Peroxidative Stress in Rats Fed on a Low Vitamin E-containing Diet by Supplementing with a Fermented Bovine Milk Whey Preparation : Effect of Lactic Acid and β-Lactoglobulin on the Antiperoxidative Action
- A New Prenylated Flavonoid from Propolis Collected in Okinawa, Japan
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols: Comparison with Wistar Rats
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose: Comparison with Wistar Rats
- Induction of Atherosclerosis in Brown Norway Rats by Immunization with Ovalbumin
- Propionate Enhances Synthesis and Secretion of Bile Acids in Primary Cultured Rat Hepatocytes via Succinyl CoA
- Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
- Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells
- Differential Effect of Walnut Oil and Safflower Oil on the Serum Cholesterol Level and Lesion Area in the Aortic Root of Apolipoprotein E-deficient Mice(Food & Nutrition Science)
- Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4
- Effects of Feeding Oyster, Crassostrea gigas, on Serum and Liver Lipid Levels in Rats
- Protection Against the Diabetogenic Effect of Feeding tert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin
- Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
- Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
- Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
- Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
- Effect of Oleic Acid Level under Constant n-6/n-3 and P/S Ratios of Dietary Fats on Lipid Metabolism in Rats(Food & Nutrition)
- The P/S Ratio of Dietary Fats and Lipid Metabolism in Rats : Gamma-linolenic Acid as a Source of Polyunsaturated Fatty Acid(Food & Nutrition)
- Slow Absorption of Conjugated Linoleic Acid in Rat Intestines, and Similar Absorption Rates of 9c,11t-Conjugated Linoleic Acid and 10t,12c-Conjugated Linoleic Acid
- Systemic Release of Mucosal Mast-cell Protease in Primed Brown Norway Rats after Feeding with β-Lactoglobulin
- Feeding Unsaponifiable Compounds from Rice Bran Oil Does Not Alter Hepatic mRNA Abundance for Cholesterol Metabolism-related Proteins in Hypercholesterolemic Rats
- Superiority of Dietary Safflower Oil over Olive Oil in Lowering Serum Cholesterol and Increasing Hepatic mRNAs for the LDL Receptor and Cholesterol 7α-Hydroxylase in Exogenously Hypercholesterolemic (ExHC) Rats
- Effects of α-Tocopherol and Tocotrienols on Blood Pressure and Linoleic Acid Metabolism in the Spontaneously Hypertensive Rat (SHR)
- Hydrolysis of Micellar Phosphatidylcholine Accelerates Cholesterol Absorption in Rats and Caco-2 Cells
- Heat-Epimerized Tea Catechins Have the Same Cholesterol-Lowering Activity as Green Tea Catechins in Cholesterol-Fed Rats
- Effects of Rat Milk on the Secretion of Cholesterol and Bile Acids from Primary Monolayer Culture of Hepatocytes of Rat Pups(Food & Nutrition)
- Modulation by Casein and Soybean Protein Amino Acid Mixtures of Insulin- and Glucagon-dependent Linoleic Acid Desaturation in Primary-cultured Rat Hepatocytes
- Effect of Antigen Dose on Induction of β-Lactoglobulin-specific IgG and IgE in Brown Norway Rats
- Effects of Dietary Palm Oil and Tocotrienol Concentrate on Plasma Lipids, Eicosanoid Productions and Tissue Fatty Acid Compositions in Rats(Food & Nutrition)
- Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats
- Preparation of Antiserum against Rat Δ6-Desaturase and Its Use to Evaluate the Desaturase Protein Levels in Rats Treated with Gemfibrozil, a Ligand for Peroxisome Proliferator-activated Receptor α(Food & Nutrition Science)
- Lymphatic Absorption of Structured Triacylglycerols, 1(3)-Stearoyl-2, 3(1)-Dilinoleoylglycerol and 2-Linoleoyl-1, 3-Distearoylglycerol in Rats
- Influence of Tea Catechins on Lipid Metabolism
- Effects of Dietary Carbohydrates on Cholesterol Metabolism in Rats of Different Ages(Food & Nutrition)
- Improved Method for Preparation of the Methyl Ester of Conjugated Linoleic Acid〔和文〕
- Comparisons of the Effects of Dietary Fats on Serum and Liver Lipid Levels of Rats
- Dietary Pine Bark Extract Reduces Atherosclerotic Lesion Development in Male ApoE-Deficient Mice by Lowering the Serum Cholesterol Level
- Identification of Nucleotide Residues Essential for RNase P Activity from the Hyperthermophilic Archaeon Pyrococcus horikoshii OT3
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats
- Slow Absorption of Conjugated Linoleic Acid in Rat Intestines, and Similar Absorption Rates of 9c,11t-Conjugated Linoleic Acid and 10t,12c-Conjugated Linoleic Acid
- N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4
- Identification of Nucleotide Residues Essential for RNase P Activity from the Hyperthermophilic Archaeon Pyrococcus horikoshii OT3
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5