Effect of Milk Whey and Its Fermentation Products by Lactic Acid Bacteria on Mitochondrial Lipid Peroxide and Hepatic Injury in Bile Duct-ligated Rats
スポンサーリンク
概要
- 論文の詳細を見る
The study was carried out to assess whether bovine milk whey and its products fermented by lactic acid bacteria could ameliorate the lipid peroxidation of hepatic mitochondria associated with cholestatic liver injury due to bile duct ligation. Rats were maintained on one of five diets for 3 weeks before being operated upon and killed 3 weeks after bile duct ligation. The diets included one deficient in vitamin E (control diet) and others supplemented with either 5o/o milk whey or 5o/o milk whey fermented with Bifidobacterium longum (B. longum), Lactobacillus acidophilus (L. acidophilus), and Streptococcus salivarius subsp. thermophillus (S. thermophilIus). Bile duct-ligated rats, compared with sham-operated rats, had higher organ weights (liver and spleen), higher serum alkaline phosphatase activity, higher serum bilirubin concentration, and higher content of hepatic mitochondrial lipid hydroperoxide. The rats fed on diets containing milk whey fermented with B. longum ameliorated the elevation of organ weights, enzyme activity, bilirubin concentration, and content of mitochondrial lipid hydroperoxide. Milk whey and milk whey fermented with L. acidophilus and S. thermophillus also suppressed the elevation of mitochondrial lipid hydroperoxide, but had no ameliorating effects on organ weights, enzyme activity, and bilirubin concentration. The elevation of serum lipid hydroperoxide was ameliorated in rats fed on diets containing milk whey and milk whey fermented with B. longum and S. thermophillus. The reduction in plasma 2-tocopherol due to bile duct ligation was ameliorated in those rats fed on diets containing milk whey fermented with B. longum as well as by S. themophillus. These results suggest that a milk whey fermented with lactic acid bacteria exerts a beneficial effect on free radical-mediated hepatic injury.
- 社団法人日本農芸化学会の論文
- 1994-07-23
著者
-
SAKONO Masanobu
Laboratory of Nutrition Chemistry, Department of Biological Resource Sciences, Faculty of Agricultur
-
Imaizumi Katsumi
Lab. Of Nutrition Chemistry Div. Of Bioresource And Bioenvironmental Sciences Graduate School Kyushu
-
Imaizumi Katsumi
Laboratory Of Nutrition Chemistry Faculty Of Bioresources And Bioenvironmental Sciences Graduate Sch
-
Imaizumi Katsumi
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
-
ZOMMARA Mohsen
Laboratory of Nutrition Chemistry, Department of Food Science and Technology, Faculty of Agriculture
-
Takagi Hironori
Laboratory of Nutrition Chemistry, Department of Food Science and Technology, School of Agriculture
-
Suzuki Yutaka
Technical Research Institute, Snow Brand Milk Products Co., Ltd.
-
Imaizumi Katsumi
Technical Research Institute, Snow Brand Milk Products Co., Ltd.
-
Zommara Mohsen
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
-
Takagi H
Department Of Food Science And Technology Faculty Of Agriculture Nagoya University:(present Address)
-
Takagi Hironori
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology School Of Agriculture (4
-
Sakono M
Univ. Miyazaki Miyazaki Jpn
-
Sakono Masanobu
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology Faculty Of Agriculture (
-
Sakano Masafumi
Department Of Applied Chemstry Graduate School Of Engineering Kyushu University Hakozaki
-
Imaizumi K
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
-
Suzuki Yutaka
Technical Research Institute Snow Brand Milk Products Co. Ltd.
関連論文
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- Intraductal Papillary Mucinous Tumor of the Pancreas in a Young Man : Report of a Case
- Structured Triacylglycerol Containing Medium-Chain Fatty Acids in sn-1(3) Facilitates the Absorption of Dietary Long-Chain Fatty Acids in Rats
- Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
- Effects of Dietary Fats and Curcumin on IgE-Mediated Degranulation of Intestinal Mast Cells in Brown Norway Rats
- Effects of Xylooligosaccharides on Blood Glucose, Serum and Liver Lipids and Cecum Short-chain Fatty Acids in Diabetic Rats(Food & Nutrition)
- Influence of Saturated and Polyunsaturated Egg Yolk Phospholipids on Hyperlipidemia in Rats(Food & Nutrition)
- Comparison of Effects of Dietary Unesterified and Esterified Plant Sterols on Cholesterol Absorption in Rats
- Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
- Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
- Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats(Food & Nutrition Science)
- Intestinal Absorbability of Wheat Allergens, Subunits of a Wheat α-Amylase Inhibitor, Expressed by Bacteria(Food & Nutrition Science)
- Concentration of Serum Lipids and Aortic Lesion Size in Female and Male Apo E-Deficient Mice Fed Docosahexaenoic Acid
- Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats
- Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
- Prevention of Peroxidative Stress in Rats Fed on a Low Vitamin E-containing Diet by Supplementing with a Fermented Bovine Milk Whey Preparation : Effect of Lactic Acid and β-Lactoglobulin on the Antiperoxidative Action
- Effect of Milk Whey and Its Fermentation Products by Lactic Acid Bacteria on Mitochondrial Lipid Peroxide and Hepatic Injury in Bile Duct-ligated Rats
- Cloning, Sequence Analysis, and Expression in Escherichia coli of the Gene Encoding Monovalent Cation-activated Levodione Reductase from Corynebacterium aquaticum M-13
- 2P009 Halomonas sp.593由来ヌクレオシドニリン酸キナーゼ(HaNDK)の多量体構造(蛋白質-構造,第48回日本生物物理学会年会)
- Induction of Atherosclerosis in Brown Norway Rats by Immunization with Ovalbumin
- Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D
- Propionate Enhances Synthesis and Secretion of Bile Acids in Primary Cultured Rat Hepatocytes via Succinyl CoA
- Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells
- Differential Effect of Walnut Oil and Safflower Oil on the Serum Cholesterol Level and Lesion Area in the Aortic Root of Apolipoprotein E-deficient Mice(Food & Nutrition Science)
- Effects of Feeding Oyster, Crassostrea gigas, on Serum and Liver Lipid Levels in Rats
- Protection Against the Diabetogenic Effect of Feeding tert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin
- Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
- Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
- Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
- Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
- Genetic Transformation of Bacillus brevis with Plasmid DNA by Electroporation(Microbiology & Fermentation Industry)
- Potential Use of Bacillus brevis HPD31 for the Production of Foreign Proteins(Microbiology & Fermentation Industry)
- Screening and Characterization of Protein-hyperproducing Bacteria without Detectable Exoprotease Activity(Microbiology & Fermentation Industry)
- Antitumor Activity of Brasilicardin A, a Novel Terpenoid Antibiotic from Nocardia brasiliensis
- Brasilicardin A, a New Terpenoid Antibiotic from Pathogenic Nocardia brasilienesis: Fermentation, Isolation, and Biological Activity
- Brasilicardin A ; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis
- Feeding Unsaponifiable Compounds from Rice Bran Oil Does Not Alter Hepatic mRNA Abundance for Cholesterol Metabolism-related Proteins in Hypercholesterolemic Rats
- Superiority of Dietary Safflower Oil over Olive Oil in Lowering Serum Cholesterol and Increasing Hepatic mRNAs for the LDL Receptor and Cholesterol 7α-Hydroxylase in Exogenously Hypercholesterolemic (ExHC) Rats
- Expression of the Cyclodextrin Glucanotransferase Gene of Bacillus macerans in Bacillus brevis
- Expression and Purification of the Bacillus subtilis Thioredoxin Superfamily Protein YkvV
- Molecular Cloning of groESL Locus, and Purification and Characterization of Chaperonins, GroEL and GroES, from Bacillus brevis
- Secretion of Hen Egg White Lysozyme from Kluyveromyces lactis
- Expression and Purification of Cytokine Receptor Homology Domain of Human Granulocyte-Colony Stimulating Factor Receptor in Escherichia coli
- Cloning and Nucleotide Sequence of the Maltopentaose-forming Amylase Gene from Pseudomonas sp. KO-8940
- Protein Refolding in Nanostructured Reversed Micelles Including a Molecular Chaperone(BIOCHEMICAL ENGINEERING)
- Rifampicin Inactivation by Bacillus species
- Purification and Characterization of 0-Acetylserine Sulfhydrylase of Corynebacterium glutamicum
- Cloning and Overexpression of the Exiguobacterium sp. F42 Gene Encoding a New Short Chain Dehydrogenase, Which Catalyzes the Stereoselective Reduction of Ethyl 3-Oxo-3-(2-thienyl)propanoate to Ethyl (S)-3-Hydroxy-3-(2-thienyl)propanoate
- Enhanced Thermostability of the Single-Cys Mutant Subtilisin E under Oxidizing Conditions^1
- 2S107 Metabolism and regulation of L-cysteine in Brevibacterium flavum (Corynebacterium glutamicum)
- Chemical Synthesis of the Gene for Microbial Transglutaminase from Streptoverticillium and Its Expression in Escherichia coli
- Molecular Cloning of the Gene for Microbial Transglutaminase from Streptoverticillium and Its Expression in Streptomyces lividans
- Gene Expression in Bacillus brevis under Control of the Lac Repressor-Operator System from Escherichia coli
- Production of Human Epidermal Growth Factor by Bacillus brevis Increased with Use of a Stable Plasmid from B. brevis 481
- 565 Charcteristics of Batch Culture of a Recombinant ___- ___- Producing a Foreign Esterase
- Modulation by Casein and Soybean Protein Amino Acid Mixtures of Insulin- and Glucagon-dependent Linoleic Acid Desaturation in Primary-cultured Rat Hepatocytes
- Effect of Antigen Dose on Induction of β-Lactoglobulin-specific IgG and IgE in Brown Norway Rats
- Monitoring and Survival of Lactobacillus gasseri SBT2055 in the Human Intestinal Tract
- Development of Gene Delivery Systems for the ε-Poly-L-Lysine Producer, Streptomyces albulus(Genetics, Molecular Biology, and Gene Engineering)
- Overexpression and Characterization of an Aminoglycoside 6'-N-Acetyltransferase with Broad Specificity from an ε-Poly-L-lysine Producer, Streptomyces albulus IFO14147
- Cloning and Analysis of the β-Lactamase Gene from ε-Poly-L-lysine-Producing Actinomycete Streptomyces albulus IFO14147
- Effect of Proline and Arginine Metabolism on Freezing Stress of Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Effect of Gene Disruption of Succinate Dehydrogenase on Succinate Production in a Sake Yeast Strain
- Engineering Subtilisin E for Enhanced Stability and Activity in Polar Organic Solvents
- Isolation and Sequence Analysis of Plasmid pNO33 in the ε-Poly-_L-Lysine-Producing Actinomycete Streptomyces albulus IFO1417
- Effect of Gene Disruption of Succinate Dehydrogenase on Succinate Production in a Sake Yeast Strain
- Characterization of Nucleoside Diphosphate Kinase from Moderately Halophilic Eubacteria(Microbiology & Fermentation Technology)
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Distribution of L-Azetidine-2-carboxylate N-Acetyltransferase in Yeast
- Rapid Detection of Acetic Acid Bacteria in the Traditional Pot-Fermented Rice Vinegar Kurozu
- 2G1624 Chromohalobacter sp.560由来β-LactamaseのX線結晶解析(蛋白質_構造2,第49回日本生物物理学会年会)
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption-Comparison with Jcl : Wistar and WKY/Izm Rats
- Effects of Cultured Milk Products by Lactobacillus and Bifidobacterium Species on the Secretion of Bile Acids in Hepatocytes and in Rats.