Linoleic Acid-Menthyl Ester Reduces the Secretion of Apolipoprotein B100 in HepG2 Cells
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概要
- 論文の詳細を見る
The effect of linoleic acid-menthyl ester (LAME) on lipid metabolism were assessed in HepG2 cells. It is well known that high level of apolipoprotein (apo) B100 in the serum is risk for atherosclerosis. Although linoleic acid (LA) treatment and LA plus L-mentol treatment increased apo B100 secretion, LAME treatment significantly decreased apo B100 secretion in HepG2 cells compared with control medium. The hypolipidemic effect of LAME was attributable to the suppression of triglyceride synthesis in HepG2 cells. It is also known that the risk of coronary heart disease is negatively related to the concentration of serum apo A-1. In the present study, LAME treatment increased apo A-1 secretion as compared with LA treatment in HepG2 cells. These results suggest that mentyl-esterification of fatty acids may be beneficial in anti-atherogenic dietary therapy.
著者
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Inoue Nao
Department of Cardiology, Juntendo University School of Medicine
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KOBAYASHI Takashi
Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medicine and Den
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YANAGITA Teruyoshi
Department of Applied Biological Sciences, Saga University
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Nagao Koji
Department of Applied Biochemistry and Food Science, Saga University
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Inoue Nao
佐賀大学 食糧科学
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Nagao Koji
Department Of Applied Biochemistry And Food Science Saga University
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SAKATA Kotaro
Department of Applied Biological Sciences, Saga University
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Yanagita Teruyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Saga University
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Shimada Yuji
Biomaterials And Commodity Chemicals Res. Div. Osaka Municipal Technical Res. Inst.
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Arao Keisuke
Department Of Applied Biological Sciences Saga University
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Nagao Toshihiro
Biomaterials And Commodity Chemicals Res. Div. Osaka Municipal Technical Res. Inst.
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Yamano Naomi
Department of Applied Biochemistry and Food Science, Saga University
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Sakata Kotaro
Department Of Applied Biochemistry And Food Science Saga University
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Inoue Nao
Department Of Applied Biochemistry And Food Science Saga University
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Yamano Naomi
Department Of Applied Biochemistry And Food Science Saga University
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Kobayashi Takashi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Nagao Toshihiro
Biomaterials and Commodity Chemicals Research Division, Osaka Municipal Technical Research Institute
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Arao Keisuke
Department of Health and Nutrition Sciences, Nishikyushu University
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Shimada Yuji
Biomaterials and Commodity Chemicals Research Division, Osaka Municipal Technical Research Institute
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Sakata Kotaro
Department of Applied Biochemistry and Food Science, Saga University
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