Comparative Study of the Effect of Basal Diet Formulation, Dietary Fat and Cholesterol Levels on the Development of Aortic Atherosclerotic Lesions in B6.KOR-Apoeshl Mice
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概要
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To optimize the adequate atherogenic diet composition for nutritional atherosclerosis studies utilizing B6.KOR-Apoeshl mice, we investigated the effect of dietary cholesterol, AIN formula, and dietary fats on the development of atherosclerosis. Cholesterol supplementation (0.15-2%) for 12 weeks resulted in a dose-dependent increase in the development of atherosclerosis. Furthermore, there were no significant differences in the degree of atherosclerosis between B6.KOR-Apoeshl mice fed a modified-AIN-76™ diet and those fed a modified-AIN-93M diet containing corn oil or soybean oil for 10 and 12 weeks. The present experiment indicates that the adequate dietary level of cholesterol was 0.15%, and that further studies are necessary to determine the optimal level of various types of dietary oils for nutritional atherosclerosis experiments in B6.KOR-Apoeshl mice.
著者
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IWASAKI Hironori
Center for Nuclear Study, University of Tokyo
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Toda Takayoshi
鹿児島大学 連合農学研究科
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Oku Hirosuke
Center Of Molecular Biosciences Tropical Biosphere Res. Center Univ. Of The Ryukyus
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Toda Takayoshi
Department Of Clinical Laboratory Medicine And Research Institute Of Comprehensive Medicine School O
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Yanagita Teruyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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Inafuku Masashi
Transdisciplinary Res. Organization For Subtropical Island Studies Univ. Of The Ryukyus
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Nukitrangsan Natthanan
United Graduate School of Agricultural Sciences, Kagoshima University
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Okabe Takafumi
United Graduate School of Agricultural Sciences, Kagoshima University
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Inafuku Masashi
Transdisciplinary Research Organization for Subtropical Island Studies, University of the Ryukyus
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Oku Hirosuke
Center of Molecular Bioscience, University of the Ryukyus
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IWASAKI Hironori
Center for Nuclear Study (CNS), University of Tokyo
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