Synthesis of Sialyl Lewis X-Polysaccharide Conjugates
スポンサーリンク
概要
- 論文の詳細を見る
Sialyl Lewis X (SLe^X) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLe^X-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions. The AUC (area under the blood concentration-time curve) 0-24 h of SLe^X-CMCht (1), SLe^X-CMPul (2) and SLe^X-DSH (3) at the inflammatory lesion was about 60-, 300-, and 30-fold higher than that of the monovalent SLe^X (7), respectively. Moreover, 1 showed 2-fold higher accumulation in the inflammatory lesion than SLN-CMCht (4), and 2 showed 2.5-fold higher accumulation than SLN-CMPul (5).
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Kawaguchi Takayuki
Drug Delivery System Institute Ltd. :(present Address)tanabe Seiyaku Co. Ltd.
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SAKAGAMI Masahiro
Drug Delivery System Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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HAMANA Hiroshi
Drug Delivery Systme Institute, Ltd., Building of Research Institute for Biosciences, The Science Un
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Hamana H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hamana H
Discovery Research Laboratories Shionogi & Co. Ltd.
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Hamana Hiroshi
Drug Delivery Systme Institute Ltd. Building Of Research Institute For Biosciences The Science Unive
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Horie Kazutoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Sakagami M
Shionogi Research Laboratories Shionogi & Co. Ltd.
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HORIE Kazutoshi
Drug Delivery System Institute, Ltd.,
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NAKAMOTO Kazutaka
Drug Delivery System Institute, Ltd.,
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Nakamoto Kazutaka
Drug Delivery System Institute Ltd. :(present Address)eisai Co. Ltd.
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Hamana Hiroshi
Dep. Of Pharmaceutical Chemistry Chiba Inst. Of Sci.
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