Syntheses of Novel Galactosyl Ligands for Liposomes and the Influence of the Spacer on Accumulation in the Rat Liver

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概要

• 論文の詳細を見る

• We modified the surface of liposomes with galactosyl ligands. At first we determined whether or not the galactosyl moiety was exposed on the liposomes. We then investigated the effect of the ligands on the hepatic accumulation of liposomes in rats. We introduced an oligoethylene glycol moiety as a spacer. Among the various ligands tested, those with a tri-or tetraethylene glycol moiety as a spacer caused the greatest accumulation of liposomes in the liver. Liposomes bearing ligands with a tri-or tetraethylene glycol moiety as a spacer, were aggregated by Ricinus communis agglutinin. On the other hand, those modified with ligands with a mono- or diethylene glycol spacer did not clearly agglutinate. These results show the importance of a spacer between the homing device and the ligand anchor.

• 社団法人日本薬学会の論文
• 1995-05-15

著者

• 佐々木 淳

  Drug Delivery System Institute Ltd. Bldg. Of Research Institute For Biosciences The Science Universt

• 佐々木 淳

  東京理科大学大学院

• 村橋 直一

  Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive

• 山田 治民

  Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive

• 森川 安理

  Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive

• 村橋 直一

  東京理科大学生命科学研究所内 (株)ディ・ディ・エス研究所

• 森川 安理

  Drug Delivery System Institute Ltd. Bldg. Of Research Institute For Biosciences The Science Universt

• 山田 治民

  (株) ディ・ディ・エス研究所

• Yamada H

  Yamada Apiculture Center Inc.

• Yamada H

  School Of Science And Technology Kwansei Gakuin University

• Yamada Harutami

  Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.

• Murahashi N

  Eisai Co. Ltd. Gifu Jpn

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