Renal Targeting of Arginine-Vasopressin by Modification with Carbohydrates at the Tyrosine Side Chain
スポンサーリンク
概要
- 論文の詳細を見る
To extend the utility of a renal targeting system using carbohydrate derivatives, we investigated the in vivo tissue distribution in rats of arginine-vasopressin (AVP) derivatives modified at the phenolic hydroxy group of tyrosine by linking it to some sugars, namely D-glucose, D-galactose, D-mannose and L-flucose, via an octamethylene group. The glycosyl and mannosyl derivatives of AVP exhibit renal-selective distribution in vivo. In addition, the glucosyl and mannosyl derivatives exhibited specific binding to the kidney microsomal fraction in vitro. Modification with D-glucose D-mannose at the tyrosine side chain is a suitable methodology for renal targeting, as well as at N-terminal amine.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
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山田 治民
(株) ディ・ディ・エス研究所
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Suzuki Kazutoshi
放射線医学総合研究所分子イメージング研究センター
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Suzuki K
Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.
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Yamada H
Yamada Apiculture Center Inc.
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Suzuki Kenji
Suntory Institute For Biomedical Research Wakayamadai
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Suzuki K
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear
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Suzuki Kokichi
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear
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Suzuki Kazutoshi
Department Of Medical Imaging National Institute Of Radiological Sciences
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Suzuki Kazutoshi
Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National
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Yamada H
School Of Science And Technology Kwansei Gakuin University
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Suzuki K
Molecular Imaging Center National Institute Of Radiological Sciences
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Okuno Satoshi
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)medicinal Chemistry
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Yamada Harutami
Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.
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SUSAKI Hiroshi
Noda Research Laboratories, Drug Delivery System Institute, Ltd.
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YAMADA Harutami
Noda Research Laboratories, Drug Delivery System Institute, Ltd.
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WATANABE Hiroshi
Noda Research Laboratories, Drug Delivery System Institute, Ltd.
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Susaki H
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)new Product Research
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Watanabe Hiroshi
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)patent Department Me
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